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Cytokeratin fragment 19 antigen (CYFRA 21-1) belongs to the cytokeratin protein family, which is mainly synthesized in epithelial tissue and forms the cytoskeleton of epithelial cells.
CYFRA 21-1 is used as a tumor marker, especially in non-small cell lung cancer, along with carcinoembryonic and squamous cell antigens. Also for other epithelial tumors such as bladder carcinoma. An increase in its concentration during a tumor is associated with cell lysis (breakdown), after which cytokeratin degradation products are released into the blood.
As other tumor markers, CYFRA 21-1 screening and diagnostic value is less, it is used to evaluate the progress of the treatment for predicting the disease.
CYFRA 21-1 is a relatively new marker defined by 2 monoclonal antibodies directed against cytokeratin fragment 19.
Immunohistochemical studies have confirmed that cytokeratin 19 is mainly found in lung carcinomas, so it is used as a marker of non-small cell lung cancer.
When is the survey conducted?
Preliminary preparation: no need
Material for examination: Venous blood
Reference norms: <3.3 ng/ml
CYFRA 21-1 is not used for lung cancer screening in asymptomatic patients or in high-risk groups (eg smokers).
Since cytokeratin 19 (CYFRA 21-1) is not an organ-specific marker, its increase in other volumetric processes is also possible.
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
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30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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