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Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: YesHuman epididymal protein 4 (HE4) is synthesized in ovarian epithelial cells. That is why it is a specific marker of ovarian epithelial cell tumors and is used for differential diagnostics and also for monitoring diagnosed epithelial cell tumors. The test determines the concentration of EH4 in the blood serum.
There are several subtypes of epithelial cells: serous, endometrial, mucinous, and clear cell. The most common serous epithelial cell tumors.
According to studies, the increase of EH4 is more typical for ovarian serous and endometrial epithelial cell tumors, less for clear cell tumors. And, in the case of mucous tumors, its concentration is almost not increased.
Human epididymal protein 4 (HE4), together with CA-125 carcinoembryonic antigen, is used to monitor ovarian epididymal tumors. The combination of these two studies allows for better monitoring.
The use of HE4 for screening in asymptomatic women is futile because it is a non-specific test. A small amount of HE4 is also synthesized by other cells, so a moderate increase in its concentration is also possible in some non-cancerous diseases.
HE4 and CA125 are part of the ovarian malignancy risk assessment algorithm (ROMA-index), which is a reliable marker for the differential diagnostics of small pelvic bulky processes.
When should we do the research?
The HE4 study may be performed in isolation, or together with CA125, to calculate the ROMA-index.
Human epididymal protein HE4: in premenopause: < 70; In postmenopause: < 140
Ovarian carcinoma antigen CA125 <35
If before the start of treatment, the concentration of the markers was significantly increased, it is recommended to control the indicators in the dynamics to evaluate the effectiveness of the treatment.
If the level of HE4 was normal before treatment, its control in dynamics is uninformative.
Increased indicators before treatment, decrease in the background of treatment - indicates positive dynamics, i.e. Treatment has results.
If after treatment, the increased concentration of HE4 does not change, this indicates the ineffectiveness of the treatment.
After surgical treatment of bulky tumors of the small pelvis, an increase in the ROMA-index probably indicates a malignant process.
In different laboratories, EH4, CA125, ROMA-index studies may be conducted with different methods, therefore, comparing the data of different laboratories in order to observe the dynamics is not recommended. It is always better to compare data from studies conducted in the same laboratory in terms of dynamics.
Study material: Venous blood
The test does not require special preliminary preparation
Response time: 14 working days
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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