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Beta-2-microglobulin is a protein on the surface of the cell membrane, mainly found in lymphocytes and tumor cells. It is a component of class I molecules of the major histocompatibility complex.
Since the synthesis of beta-2-microglobulin in the body takes place mainly in lymphocytes, therefore, all diseases involving the proliferation of lymphocytes are characterized by an increase in the concentration of this protein: lymphomas, multiple myeloma, chronic lymphocytic leukemia, Hodgkin's lymphoma, and others.
During such diseases, which are characterized by an increase in cellular immune reactions - autoimmune diseases, infectious mononucleosis, the reaction of transplant cells and others - are also characterized by an increase in the plasma concentration of beta-2-microglobulin.
Beta-2-microglobulin affects renal glomerular filtration and tubular reabsorption. Accordingly, an increase in its level in the blood is often associated with kidney glomerular damage, while a decrease in its concentration in the serum, and an increase in the urine indicates damage to the renal tubular system.
An increase in plasma beta-2-microglobulin concentration is also observed during acute or reactivated cytomegalovirus infection.
In patients with immunodeficiency virus, especially with opportunistic infections, the concentration of serum beta-2-microglobulin is elevated.
Determination of beta-2-microglobulin is an informative marker both for diagnostics and for evaluating the progression of the disease.
Multiple myeloma
Hodgkin's disease
Chronic lympho-leukemia
HIV infection (assessment of disease progression)
Graft removal reaction
Cytomegalovirus infection
Follow-up of kidney transplantation
Preparation of the patient: The study is conducted on an empty stomach
Study sample: Venous blood
Norms are defined only for adults 22-64 years old
0.6 mg/L (2.5 percentile) – 2.366 mg/L (97.5% percentile)
The rate of increase in the concentration of beta-2-microglobulin in serum or urine is informative only in the clinically manifested form of the disease.
In chronic lympho-leukemia, the level of beta-2-microglobulin increases proportionally to the progression of the disease.
In large cell non-Hodgkin lymphoma, beta-2-microglobulin and lactate dehydrogenase are prognostic markers of the disease.
In Hodgkin's lymphoma, beta-2-microglobulin is a prognostic indicator of disease activity.
Determination of beta-2-microglobulin is a valuable routine diagnostic method in multiple myeloma. A sharp increase in its index is associated with a bad prognostic outcome.
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
53 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Kabali village, Dusheti, Kareli, Tianeti.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
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577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2024, the Synevo Georgia network will include 3 clinical laboratories and 53 blood sampling units, which will perform more than 300,000 tests.
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