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Coagulation factor XII or Hagemann's factor is a glycoprotein synthesized in the liver, which together with prekallikrein and high molecular weight kininogen forms a contact-activation system. These factors are essential for in vitro thrombus formation as determined by the activated partial thromboplastin time (APTT). In a test tube (in-vitro), factor XII is activated upon contact with negatively charged surfaces.
In case of deficiency of this factor, hemorrhagic manifestations are not observed, because physiological coagulation occurs in an alternative way, bypassing the contact-activation system.
FXII deficiency is a genetic disorder with autosomal recessive inheritance. Heterozygous (simultaneous presence of a healthy and mutated gene) condition is more common and occurs in 1,5-3% of the population. Factor FXII deficiency is the most common cause of APTT prolongation in patients with no history of hemorrhagic syndrome and a negative lupus anticoagulant.
In homozygous (both mutated genes) individuals, factor xii activity is <1% and may be associated with APTT prolongation >100 seconds.
Factor XII changes (both increase and decrease) may be detected in specific clinical conditions, such as: septicemia, coronary artery diseases, pharmacological thrombolysis, inflammatory bowel diseases, pregnancy, lactic acidosis, dialysis, angioedema.
Determination of factor XII is recommended to determine the causes of APTT prolongation even when it is not associated with bleeding.
Preparation of the patient: The study is conducted on an empty stomach
Material for examination: Venous blood
Reference norms
50-150%
1-15 weeks of pregnancy: 50-150 %
16-40 weeks of pregnancy: 50-170%
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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