Protein C | Activity

General Information

For researchPatternTakingIt will happen:

• In the regions: Thursday
• In Tbilisi:on Thursdayor/And on Friday (Of the dayfirstin half)

SamplesSendWill be implementedOn Friday,Of the daysecondHalfway!For this,SampleSentCentralin the laboratoryShouldTo be sentFriday at 12:00till

Protein C is a glycoprotein synthesized in the liver (with the participation of vitamin K), circulates in plasma and participates in the prevention of thrombosis. Its anticoagulant function is manifested by the inactivation of factors V and VIII. It also acts as a pro-fibrinolytic (fibrin-breaking) agent.

Protein C is activated by thrombin. The acceleration of activation is mediated by the interaction between thrombin and thrombomodulin on endothelial cells.

Activated protein C removes activated factors V and VIII by proteolytic cleavage, thereby reducing the coagulation activity of plasma. The inactivation of coagulation factors requires the presence of the cofactor protein S, as well as calcium and phospholipids on the surface of the cell membrane. Activated protein C is neutralized by alpha-2-antiplasmin and alpha-2-macroglobulin.

Protein C deficiency can be congenital or acquired. In the case of congenital deficiency, the severity of clinical manifestations depends on the homozygous or heterozygous status of the gene alleles.

Heterozygous Individuals present with deep vein thrombosis, with or without pulmonary embolism, at a young age.

Homozygous In some cases, massive thrombosis occurs immediately after birth, causing neonatal purpura and death.

Acquired protein C deficiency occurs in liver disease, disseminated intravascular coagulation syndrome, insulin-dependent diabetes mellitus, essential hypertension, sickle cell anemia, malignancies, and treatment with oral anticoagulants or L-asparaginase.

Patient preparation

The study is performed on an empty stomach. Oral anticoagulants should be discontinued 2 weeks prior to the study.

Research material – Venous blood

Protein CReference boundaries

70-140%