General Information
Prothrombin Is a protein synthesized by the liver and is one of the important factors that promotes blood clotting. Normal coagulation requires several types of proteins called coagulation factors. In the process of coagulation they must act properly and in sufficient quantities.
When should we take the test?
- Evaluation of the activity of vitamin K-dependent coagulation factors.
- Suspected congenital deficiency of coagulation factors (hereditary hemophilia and II, V, VII, X and fibrinogen factors).
- Monitoring treatment with anticoagulants (syndrome, etc.).
- Monitor liver function (assess its protein-producing function) and detect its abnormalities.
- Eliminate blood clotting disorders before surgery or invasive procedures.
- Suspicion of DIC syndrome (disseminated intravascular coagulation syndrome).
- Suspicion of dysphibrinogenemia.
- Suspicion of vitamin K deficiency.
- When prone to bleeding (prolonged bleeding, frequent bleeding, bleeding from the nose and gums, spontaneous ecchymoses)
- Venous thrombosis.
- Recommended for Sars-cov2 infection to monitor thrombosis prevention.
It is advisable to perform the above tests:
- For annual prophylactic examinations. The frequency of coagulation test for prophylaxis depends on the age of the patient: for young people it is recommended once a year, for the elderly - once every 6 months.
- See also When infected with SARS-CoV-2, To prevent thrombosis.
The examination is prescribed by a doctor.
Possible interpretation of the results
Prothrombin time is usually measured in seconds, but can also be expressed in other ways:
- Measured In seconds: The norm in healthy patients - 10-14 seconds
- Measured In percentages: Normal prothrombin activity - > 70%.
- Measured By INR: The norm in healthy patients - INR 0.8 - 1.2.
- Therapeutic interval in patients receiving oral anticoagulant therapy: INR 2,0 - 3,0.
PT
Prolongation of prothrombin time Means inhibition of blood clotting and is manifested in the following cases:
- Anticoagulant therapy.
- Impaired liver function.
- Insufficient amount of blood clotting proteins.
- Vitamin K deficiency.
- Deficiency of other coagulation factors (f. II, V, VII or X).
- DIC syndrome.
- Presence of blood clotting inhibitors.
Reduced prothrombin time Means accelerated blood clotting and has no clinical significance. Manifested in the following cases:
- Take vitamin K supplements.
- Take large amounts of vitamin K products (green tea, liver, broccoli, soy).
- Estrogen-containing drugs or hormone replacement therapy.
INR
The INR is evaluated in patients treated with oral anticoagulants and its determination serves to monitor dose and dose intervals.