What are coagulation tests?

Name: Coagulogram | PT (sec,%), INR, APTT
Brand: სინევო
SKU: 1945
Price: 31.5 GEL
Availability: InStock
Rating: 5 (1 reviews)

Coagulation tests — These are blood tests that evaluate Blood clotting ability და The work of blood clotting (coagulation) factors

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Coagulogram | PT (sec,%), INR, APTT

Synevo editorial team

Known as: Coagulogram

SKU: 1945

Original price was: ₾35.00.Current price is: ₾31.50.

Study material: Venous blood

Response time (working days): 1 ****

The test is done on an empty stomach: Yes

Home call service: Yes

Country: Georgia

Laboratories❯

General Information

Coagulation It is a process in the body that occurs when the integrity of blood vessels is disrupted and prevents the development of life-threatening bleeding. However, under normal conditions, blood moving in a blood vessel does not clot. In pathological cases, a thrombus formed in the bloodstream can enter vital organs such as the heart, brain, lungs and cause disruption of blood circulation in these organs and even death.

Coagulation tests determine the ability of blood to clot and the time it takes for it to clot.

When should we take the test?

aPTT

Control and monitoring of therapy with non-fractional heparin and thrombin inhibitors (hirudin, argatroban).
Diagnosis of congenital or acquired failure of certain coagulation factors (XII, XI, IX, VIII, VII), suspicion of hemophilia or von Willebrand disease.
Determine the presence of specific or nonspecific coagulation inhibitors (lupus anticoagulant, antiphospholipid antibodies).

PT

Evaluation of the activity of vitamin K-dependent coagulation factors.
Suspected congenital deficiency of coagulation factors (hereditary hemophilia and II, V, VII, X and fibrinogen factors).
Monitoring treatment with anticoagulants (syndrome, etc.).
Monitor liver function (assess its protein-producing function) and detect its abnormalities.
Eliminate blood clotting disorders before surgery or invasive procedures.
Suspicion of DIC syndrome (disseminated intravascular coagulation syndrome).
Suspicion of dysphibrinogenemia.
Suspicion of vitamin K deficiency.
When prone to bleeding (prolonged bleeding, frequent bleeding, bleeding from the nose and gums, spontaneous ecchymoses).
Venous thrombosis.

It is advisable to perform the tests included in the complete coagulation profile:

For annual prophylactic examinations. The frequency of coagulation test for prophylaxis depends on the age of the patient: for young people it is recommended once a year, for the elderly - once every 6 months.
See also When infected with SARS-CoV-2, To prevent thrombosis.

The examination is prescribed by a doctor.

Possible interpretation of the results

aPTT

Prolongation of aPTT connected:

All congenital deficits (including hemophilia A and B, von Willebrand disease)
Thrombin inhibitors (hirudin, argatroban)
Streptokinase
Urokinase
Oral anticoagulant therapy
Vitamin K deficiency
Malnutrition
Intravascular coagulation syndrome
Existence of fibrin degradation products
Presence of circulating factor-specific anticoagulants
Nonspecific - Lupus anticoagulants

Normal PT (prothrombin time) prolonged aPTT: Deficiency of precalicine or one of the VIII, IX, XI and / or XII factors is likely.
Prolonged PT normal aPTT: A possible deficiency of factor VII is likely. Nutritional or therapeutic deficiency of vitamin K-dependent factors can sometimes lead to prolonged PT and normal aPTT.
Extended PT and aPTT:Deficiency of factor I, II, V or X is likely.

Reduction of aPTT connected:

Increased levels of one factor, most often factor VIII
Common neoplasms (except when the liver is damaged)
Acute bleeding
Early stage of DIC

A prolonged aPTT indicates hemorrhagic disease, and a decreased aPTT has been found to be an independent predictor of death in patients with a high risk of thrombosis and bleeding.

aPTT depends on the patient's age: in newborns, the upper limit of aPTT extends up to 55 seconds and gradually decreases to the values typical for adults by 6 months; Prolonged aPTT values in healthy children are caused by mild deficiencies of several coagulation proteins. In the elderly, aPTT may decrease.

PT

Prolongation of prothrombin means a delay in blood clotting and is manifested in the following cases:

Anticoagulant therapy.
Impaired liver function.
Insufficient amount of blood clotting proteins.
Vitamin K deficiency.
Deficiency of other coagulation factors (f. II, V, VII or X).
DIC syndrome.
Presence of blood clotting inhibitors.

Reduced prothrombin time means accelerated blood clotting and has no significant clinical significance. Manifested in the following cases:

Take vitamin K supplements.
Take large amounts of vitamin K products (green tea, liver, broccoli, soy).
Estrogen-containing drugs or hormone replacement therapy.

INR

The INR is evaluated in patients treated with oral anticoagulants and its determination serves to monitor dose and dose intervals.

Other tests

Testing process


Purchase a test	Submission of material


Results Online	Consult a doctor

Resources

aPTT / аПТТ – activated partial thromboplastin time

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This medical information is not intended to be a universal treatment guide for all patients. The treatment process, including the type, volume, and frequency of diagnostic tests and therapeutic procedures, is determined by the physician individually — based on an assessment of the patient's condition and relevant medical indications. The decision is made in consultation with the patient. Before purchasing a test, please read the instructions for its preparation.