Very Low Density Lipoproteins (VLDL)

VLDL (very low density lipoprotein) Synthesized in the liver. Circulating free fatty acids in the liver produce triglycerides that bind to apoproteins and cholesterol and then pass into the bloodstream as VLDL. Their main function is to transport triglycerides synthesized in the liver to fat and muscle cells. They act as Precursors of LDL (low density lipoproteins). LDL Contains 60-70% of total serum cholesterol, formed as a result of the breakdown of VLDL. The major LDL protein is apoprotein B (apo-B). Although the half-life of LDL is longer (3-4 days) than that of its predecessor or VLDL, it is more abundant in circulation than VLDL. LDL cholesterol is involved in the transport of cholesterol to tissues, primarily the arterial system, which explains the high risk of developing atherosclerosis and coronary heart disease in patients with elevated levels of this lipoprotein. Thus, the determination of LDL is a specific test to assess the risk of cardiovascular disease and to determine therapeutic procedures.

When should we test for very low density lipoproteins?

• Risk assessment for ischemic heart disease;
• Diagnosis of hyperlipoproteinemia;
• Atherosclerosis and diseases of the cardiovascular system;
• Liver disease;
• In the ages;
• Obesity;
• arterial hypertension;
• diabetes.

VLDL Cholesterol screening is mainly done by examining the following parameters: total cholesterol, LDL Cholesterol, HDL Cholesterol and triglycerides.

How to prepare for the test?

Blood sampling is required for analysis (at least 12 hours after the last meal).

Some medications can affect test results, so it is important to consult your doctor and get detailed instructions to prepare for the test.

Research material

Venous blood

Possible interpretation of the results

LDL-He and VLDLOf Levels can be increased:

• Hereditary hypercholesterolemia (type IIa);
• Hyperlipoproteinemia II-B and III;
• A diet rich in high cholesterol and saturated fats;
• Hypothyroidism;
• Nephrotic syndrome;
• diabetes;
• Multiple myeloma and other dysgammaglobulinemia;
• Chronic renal failure;
• Porphyria;
• Anorexia nervosa;
• After eating fatty foods;
• Pregnancy.

LDL-He and VLDLOf Levels can be reduced:

• Hypobetalipoproteinemia;
• Hyperthyroidism;
• Chronic anemia;
• Severe hepatocellular diseases;
• Severe stress;
• Inflammatory diseases of the joints;
• Chronic lung disease.

Resources

https://spravochnik.synevo.ua/ru/lipidniy-obmen/lipoproteids-fractions.html

https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=vldl_cholesterol