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₾125.00
Study material: 24-hour clock
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: YesVanillmandelic and homovanillic acid
The homovanillic acid (HVA) and vanillinmandelic acid (VMA) test in urine is used to screen children for catecholamine-associated tumors: neuroblastoma, pheochromocytoma, and other tumors. Also to monitor the treatment of these tumors.
In addition, the homovanillic acid test in children is used to diagnose disorders of catecholamine metabolism, such as monoamine oxidase-A and dopamine-beta-hydroxylase deficiency, which cause changes in the concentration of homovanillic acid in the urine.
Referral norms
Vanillmandelic acid
1-7 years: < 2,2
7-10 years: < 3,8
10-99 years: <6,5
Homovanilic acid:
0-99 years: < 8,0
Interpretation of results:
Increases in homovanillin, vanillylmandelic acid, and other catecholamine metabolites are usually associated with catecholamine-synthesizing tumors. The study of these metabolites is also used to monitor the treatment of these tumors. In monoamine oxidase A deficiency, the concentration of homovanillic acid in the urine is usually reduced. Whereas, a deficiency of dopamine beta-hydrolase (the enzyme that converts dopamine to norepinephrine) causes an increase in the concentration of homovanillic acid in the urine.
Concentrations of vanillinmandelic and homovanillic acid are elevated in more than 90% of neuroblastoma cases, but additional studies are required if the test is positive.
A normal test result does not exclude the diagnostics of a catecholamine-synthesizing tumor.
An increase in homovanillic and vanillylmandelic acid is also characteristic of pheochromocytoma.
Material for examination: 24 hour urine.
Preliminary preparation: L-DOPA drugs and antibiotics of the sulfonamide group cause a false increase in vanillinmandelic and homovanillic acid concentrations, so the doctor should have information about the medications the patient is taking.
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