Uric acid (liquor) | Laboratory research

General Information

Uric acid Is a metabolic product of purine nucleosides (they form nucleic acids - RNA and DNA). It can occur during food intake and as a result of the body breaking down its own nucleic acids. From the liver, uric acid travels through the blood to the kidneys, where about 70% of it is filtered and excreted from the body. The rest of the uric acid is excreted and broken down in the gastrointestinal tract.

Small amounts of purines are found in the body when ingesting certain foods such as liver, seafood, dried peas and beans, as well as in certain alcoholic beverages, mainly beer. This can lead to an increase in blood uric acid or so-called hyperuricemia.

Under the influence of digestive enzymes, food purines are broken down to uric acid already in the gastrointestinal tract, after which it is absorbed into the bloodstream. The uric acid absorbed into the blood is excreted by the kidneys.

In blood plasma uric acid is in the form of a salt - sodium urate. This salt has a low solubility and at slightly higher concentrations than its norm, crystals of sodium urate are formed.

Excess production of uric acid occurs in the following conditions: excessive catabolism of nucleic acids, massive destruction of cells or inability to separate the final product. Although hyperuricemia and hypouricemia are not independent diseases, hyperuricemia is a risk factor for the development of metabolic disorders and may be the basis of some diseases, while hypouricemia may indicate a latent pathological condition.

Blood uric acid levels are labile and are associated with factors such as age, sex, and alcohol consumption.

When should we take the test?

Uric acid is one of the indicators of purine metabolism disorder.

• Evaluation of renal function in renal failure;
• Gout;
• Urolithiasis;
• Monitoring of cytostatic therapy;
• Gestosis monitoring in dynamics during pregnancy;
• Proliferative diseases of the lymphatic system;

With the following symptoms:

• Hypersensitivity or joint pain;
• Swelling in the joint area;
• Redness of the skin around the joint, radiant and warm skin.

The test is prescribed by a doctor.

How should we prepare for the test?

Fasting is recommended for the test.

The test is preferable in the morning because blood uric acid levels vary at different times of the day - usually higher in the morning and lower in the evening.

Research material

Venous blood

Possible interpretation of the results

Uric acid concentration increases:

• Renal failure;
• Gout;
• Asymptomatic hyperuricemia;
• Leukemia and chronic myeloproliferative syndrome, multiple myeloma, lymphomas;
• Anti-cancer chemotherapy;
• Hemolytic anemia, pernicious anemia;
• Toxicosis in pregnant women;
• Psoriasis;
• Poisoning (barbiturates, methyl alcohol, ammonia, carbon monoxide);
• Metabolic acidosis, diabetic ketoacidosis, hypertriglyceridemia;
• Low-fat diet, alcohol consumption;
• Lead poisoning (lead-induced nephropathy);
• Polycystic kidney disease;
• Girke disease, Les Nihan syndrome, Down syndrome;
• Hyperparathyroidism, hypothyroidism.

Decreased uric acid concentration:

• Wilson-Konovalov disease, Fancon syndrome;
• Acromegaly;
• Celiac disease;
• Xanthinuria (xanthinoxidase deficiency);
• Hodgkin's disease;
• Bronchogenic cancer;
• Defects of the proximal tubules of the kidneys;
• Low-purine diet.

Resources

https://spravochnik.synevo.ua/ru/klinicheskaia-himia/mochevaia-kislota.html

https://www.synevo.bg/pikochna-kiselina-serum/

https://www.synevo.ro/shop/acid-uric-seric/