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Urea Is the end product of protein metabolism in the body. The major site of urea production is the liver, however, tissue during growth (e.g., embryonic tissue or tumor tissue) tends to produce urea from arginine.
Most of the urea is excreted by glomerular filtration; 40-60% is reabsorbed into the blood, depending on the rate of flow in the tubules and the concentration of antidiuretic hormone (ADH).
Urea is one of the indicators of impaired nitrogen metabolism.
Urea concentration increases:
Urea concentration decreases:
Changes in urea concentration in the blood and urine are directly proportional to the protein diet and inversely proportional to the increase in cell anabolism, pregnancy, and recovery.
In addition, the concentration of urea in plasma depends on its absorption by the kidneys: with adequate diuresis, urea uptake into the blood from the distal tubules is reduced to a minimum, large amounts of urea are excreted in the urine, and serum urea levels remain low; If there is a decrease in diuresis, such as oliguria in thirst, excitability, heart failure, urea is reabsorbed from the distal tubules into the blood, and plasma urea levels increase.
Persistently elevated levels of serum urea indicate significant changes in glomerular filtration rate. With normal protein intake (100 g per day) and normal renal absorption, no increase in serum urea is observed until the glomerular filtration rate is reduced to 30 ml / min.
In pronounced renal insufficiency, serum urea concentration correlates with glomerular filtration rate. In chronic renal failure with polyuria or vomiting, accompanying diarrhea, liver failure, urea levels may not rise more than predicted. On the other hand, in chronic renal failure with oliguria, increased protein intake, heart failure, gastrointestinal bleeding, urea levels may be higher than expected.
Fasting is recommended for the test.
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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