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Thyroid Stimulating Hormone (TSH) Is a glycoprotein produced in basophilic cells of the anterior pituitary gland. TSH is released by a negative feedback mechanism in response to changes in the concentration of free triiodothyronine and free thyroxine. It consists of two chains - α and β. The α chain is common for TSH, follicle-stimulating hormone (FSH), melatoninizing hormone (LH), and chorionic gonadotropin-releasing hormone (hCG). The beta chain is different and determines its biochemical specificity. TSH has a circadian rhythm of secretion controlled by hypothalamic-releasing TSH-releasing hormone (TRH).
TSH levels are high In primary hypothyroidism.
If there are obvious signs of hypothyroidism but TSH levels are not elevated, secondary (central) hypothyroidism is suspected in hypopituitarism. In this case the biological activity of TSH is low.
Decreased levels of TSH Found in hyperthyroidism.
It is observed in pregnant women TSH tendency to decrease.
The incidence of TSH inhibition in hospitalized patients is twice as high as in patients with hyperthyroidism in patients without thyroid disease.
The concentration of TSH increases slightlyWith age A.
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