Soluble interleukin 2 receptor (IL-2R)

General Information

The soluble interleukin-2 receptor plays an important role in the regulation of the immune system. This receptor is located on the surface of the T lymphocyte. Binding of interleukin 2 to the receptor activates the intracellular signaling processes of the lymphocyte and ensures lymphocyte proliferation. In this way, T helpers, T suppressors and cytotoxic T cells are formed, which participate in immune reactions.

Interleukin 2 receptor is a membrane protein, which consists of three α, β, γ subunits. The α-subunit is the soluble form. Simultaneously with the strengthening of receptor (protein) synthesis on the cell surface, its concentration in the blood also increases.

Thus, the increase in the concentration of the soluble receptor of interleukin 2 in the blood is directly correlated with the increase in the activity of T and B lymphocytes.

An increase in the concentration of the soluble receptor of interleukin 2 in the blood is observed in the following conditions:

• Acquired immunodeficiency syndrome
• Autoimmune diseases
• Sarcoidosis
• Some forms of lymphomas
• leukemias
• Graft removal reaction

When is the survey conducted?

• Monitoring of pulmonary and extrapulmonary forms of sarcoidosis
• Malignant non-Hodgkin's lymphoma, unspecified lymphomas
• Monitoring of T lymphocyte activity in HIV-positive patients

Preparation of the patient: The research can be carried out on an empty stomach or after a meal.

Material for examination: Venous blood

Reference norm: < 710 units/ml