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Sodium is excreted from the body mainly by the kidneys. Renal excretion of Na+ is influenced by changes in glomerular filtration rate, serum Na+ concentration, adrenocortical activity, amount of nonabsorbable substances in the filtrate, and extracellular fluid volume. Each of these five parameters affects the amount of Na+ filtered or reabsorbed differently. The amount of Na+ that appears in the urine is the difference between the amount filtered by the glomerulus and the amount reabsorbed in the tubular lumen. Urinary excretion of Na+ is usually only 1% of the filtered amount.
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