Sjogren's syndrome-associated antigen A|autoantibodies anti-Ro/SSA

General Information

ENA extractable nuclear autoantibodies  It is a part of antinuclear antibodies and develops against different classes of nuclear proteins:

Anti-SS-A

Anti-SS-B

Anti-RNP

Anti-SM

Anti-SCL-70

Anti-JO-1

Anti-SS-A  – The most commonly detected ENA antibody. It is associated with Sjogren's syndrome, systemic lupus erythematosus, its subacute subcutaneous course, neonatal lupus, etc.

Anti-SS-B  -  It is a typical marker of autoimmune connective tissue diseases. It occurs in Sjogren's disease, scleroderma, myositis, systemic lupus erythematosus.

Anti-RNP   -    Autoantibodies against ribonucleoproteins. It occurs in 45% of patients with systemic lupus erythematosus, however, it is also characteristic of other connective tissue diseases: Sjogren's syndrome, scleroderma and polymyositis.

Anti-SM  -    Smith's autoantibodies are formed against small nuclear ribonucleoprotein - Smith, which consists of B, B1, D, E, G protein subunits. Smith's autoantibodies are typical of systemic lupus erythematosus and are present in 30% of patients.

Anti-SCL-70  -    Autoantibodies are present in 20% of patients with systemic scleroderma and often indicate a poor clinical prognosis.

Anti-JO-1  -   It is an autoantibody characteristic of myositis, which occurs in patients with idiopathic inflammatory myopathies. These antibodies are directed against histidyl transport RNA synthetase and inhibit histidyl attachment to transport RNA during protein synthesis.

It is often associated with a form of polymyositis and dermatomyositis with lung damage. The anti-JO-1 antibody titer correlates directly with disease activity.

When Let's hold on test extractable  antinuclear on antibodies?

•  When autoimmune systemic disease of connective tissue (collagenosis) is suspected
• To diagnose and evaluate the activity of such diseases as systemic lupus erythematosus, progressive systemic sclerosis, Sjogren's syndrome, polymyositis/dermatomyositis.