Sjogren's syndrome-associated antigen A | autoantibodies anti-Ro/SSA

Possible interpretation of the results

Anti-SS-A – The most commonly detected ENA antibody. It is associated with Sjogren's syndrome, systemic lupus erythematosus, its subacute subcutaneous course, neonatal lupus, etc.

Anti-SS-B    It is a typical marker of autoimmune connective tissue diseases. It occurs in Sjogren's disease, scleroderma, myositis, systemic lupus erythematosus.

Anti-RNP     Autoantibodies against ribonucleoproteins. It occurs in 45% of patients with systemic lupus erythematosus, however, it is also characteristic of other connective tissue diseases: Sjogren's syndrome, scleroderma and polymyositis.

Anti-SM   Smith's autoantibodies are formed against small nuclear ribonucleoprotein - Smith, which consists of B, B1, D, E, G protein subunits. Smith's autoantibodies are typical of systemic lupus erythematosus and are present in 30% of patients.

Anti-SCL-70   Autoantibodies are present in 20% of patients with systemic scleroderma and often indicate a poor clinical prognosis.

Anti-JO-1  It is an autoantibody characteristic of myositis, which occurs in patients with idiopathic inflammatory myopathies. These antibodies are directed against histidyl transport RNA synthetase and inhibit histidyl attachment to transport RNA during protein synthesis.

It is often associated with polymyositis and dermatomyositis with pulmonary involvement. The titer of anti-JO-1 antibodies is directly correlated with disease activity.