Saccharomyces cerevisiae Antibodies IgG, IgA (Crohn's disease, ulcerative colitis)

General Information

Anti-Saccharomyces cerevisiae (ASCA) antibodies are immune proteins that are often found in people with inflammatory bowel disease.
Saccharomyces cerevisiae are yeast fungi found in food products. The relationship between the presence of Saccharomyces cerevisiae antibodies and autoimmune inflammatory processes of the intestine is still unclear.
The symptoms and severity of inflammatory bowel diseases are different in different patients and may change over time. Crohn's disease and ulcerative colitis are the most common inflammatory bowel diseases. Crohn's disease can affect any part of the gastrointestinal tract, while ulcerative colitis affects the large intestine. These diseases are usually diagnosed by endoscopic examination and examination of intestinal biopsy material.
Saccharomyces cerevisiae antibodies are more common in Crohn's disease than in ulcerative colitis.
There are two classes of Saccharomyces cerevisiae antibodies: IgA and IgG. IgG determines the course of the disease and the course of treatment.

Why is the test conducted??
For differential diagnostics between Crohn's disease and ulcerative colitis.

Study material: Venous blood
Preliminary preparation: not necessary
How is research used?
Primary diagnostics of inflammatory bowel diseases is based on instrumental research and biopsy results, however, in some cases it is still difficult to distinguish between ulcerative colitis and Crohn's disease with these research methods.
Anti-Saccharomyces cerevisiae antibodies are often tested for perinuclear antineutrophil cytoplasmic antibodies (pANCA).
The presence of Saccharomyces cerevisiae antibodies is more typical for Crohn's disease, and pANCA for ulcerative colitis.