Rodinia – Thrombophilia and NAIT panel (additional panel when conducting a couple infertility panel**) (22 options)

General Information

**You will receive the study at the indicated price, Rodinia – Female and Male Infertility Panel in Couples (55 Genes / 40 Genes) After conducting, as an additional study.

Sampling for research will be done:

• In the regions: Thursday   
• In Tbilisi: Thursday and/or Friday (in the first half of the day)

Samples will be sent on Friday afternoon! For this, the sample must be sent to the central laboratory by Friday 12:00.

What is the Rodinia Thrombophilia and NAIT panel?

The Thrombophilia and Neonatal Alloimmune Thrombocytopenia (NAIT) panel identifies genetic variations that increase the risk of conditions such as:

• Early or late termination of pregnancy
• Thrombosis
• Neonatal alloimmune thrombocytopenia

(Neonatal alloimmune thrombocytopenia (NAIT) is a rare but serious condition in newborns caused by the mother's immune system attacking the fetus' platelets during pregnancy.)

The panel ensures the identification of individuals at risk before life-threatening conditions develop, allowing for management of the condition and reduction of complications.

Rodinia – Thrombophilia and NAIT Panel (standalone panel) can be used both individually and as an additional test in male and female infertility panel studies.

Who is the test for?

• Couples and individuals with more than one prematurely terminated pregnancy
• Newborns with thrombocytopenia
• Individuals with an early onset episode of thrombocytopenia or a clear family history.
• Individuals with recurrent episodes of thrombosis
• Newborns with unexplained thrombosis

Study sample: Cheek swab

How many genes are being studied?

The panel will examine 17 genetic variants in 22 genes.

genes

NM_000130.4(F5):c.1601G>A (p.Arg534Gln). NM_000130.4(F5):c.3980A>G (p.His1327Arg). NM_000129.3(F13A1):c.103G>T (p.Val35Leu). NM_000212.2(ITGB3):c.176T>C (p.Leu59Pro). NM_000173.7(GP1BA):c.482C>T (p.Thr161Met). NM_000419.5(ITGA2B):c.2621T>G (p.Ile874Ser). NM_000212.2(ITGB3):c.506G>A (p.Arg169Gln). NM_002203.4(ITGA2):c.1600G>A (p.Glu534Lys). NM_000212.2(ITGB3):c.1544G>A (p.Arg515Gln). NM_000602.5(SERPINE1):c.-820G[(4_5)]. NM_005957.5(MTHFR):c.665C>T (p.Ala222Val). NM_005957.4(MTHFR):c.1286A>C (p.Glu429Ala). NM_000789.3(ACE):c.2306-117_2306-116insAF118569.1:g.14094_14382. NM_000384.3(APOB):c.10580G>A (p.Arg3527Gln). NM_000041.2(APOE):c.526C>T (p.Arg176Cys). NM_000041.4(APOE):c.388T>C (p.Cys130Arg). NM_000254.2(MTR):c.2756A>G (p.Asp919Gly). NM_002454.3(MTRR):c.66A>G (p.Ile22Met). NM_000029.4(AGT):c.803T>C (p.Met268Thr). NM_031850.3(AGTR1):c.*86A>C. NM_000852.4(GSTP1):c.313A>G (p.Ile105Val). NM_000506.5(F2):c.*97G>A.