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Rheumatoid factor (RF) Is a heterogeneous group of autoantibodies to the body's own immunoglobulin that has changed its properties under the influence of a virus or other agent. They are usually IgM antibodies, but may also be IgG and IgA antibodies.
RF is synthesized by plasma cells of the synovial membrane. Autoantibodies can form immune complexes with both complement system proteins and other proteins. Upon entering the synovial fluid, autoantibodies are phagocytosed and destroyed by neutrophils, which induces the release of inflammatory mediators that damage joint tissue.
Autoantibodies can also form large protein complexes that fail to phagocytose and are therefore deposited around blood vessels in the intercellular space, leading to the development of an inflammatory reaction - vasculitis.
RF is not involved in initiating the inflammatory process that causes rheumatoid arthritis, although it is likely to contribute to the aggravation and persistence of the process.
RF may appear in the body before the onset of the disease and sometimes several years before the clinical manifestation of the disease.
According to the presence / absence of rheumatoid factor, rheumatoid arthritis is divided into 2 categories: seropositive or seronegative. The risk of developing erosive arthritis in seropositive patients with rheumatoid arthritis, with loss of joint function and external manifestations, is several times higher than in seronegative patients.
HIV-positive patients are at high risk of developing seronegative arthritis with loss of joint function and external manifestations such as rheumatoid nodules, lung disease, vasculitis, Felt syndrome (neutropenia and splenomegaly associated with rheumatoid arthritis).
RF is not specific for rheumatoid arthritis and is also defined in other connective tissue diseases and some chronic infections (endocarditis, tuberculosis, hepatitis B).
The test should be performed on an empty stomach.
Venous blood
RF level increases:
The absence of RF does not rule out the diagnostics of rheumatoid arthritis, especially in the case of a single examination.
https://spravochnik.synevo.ua/ru/klinicheskaia-himia/rheumatoid-factor.html
https://www.synevo.ro/shop/factor-reumatoid/
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
53 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Kabali village, Dusheti, Kareli, Tianeti.
Use the Synevo web platform to view results from anywhere and anytime
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30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2024, the Synevo Georgia network will include 3 clinical laboratories and 53 blood sampling units, which will perform more than 300,000 tests.
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