Neisseria gonorrhea | DNA (PJR in real time)

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Neisseria gonorrhoeae is characterized by tropism to the epithelium of the vagina, urethra, endocervical canal, rectum, larynx, conjunctiva. As a result of bacteremia (occurs in less than 1% of cases), peritoneal inflammation may develop. Asymptomatic transmission of the infection, which contributes to the development of complications due to the lack of treatment, is characteristic of 50-90% of women and 10% of men. It should be noted that Neisseria gonorrhoeae is associated with an increased risk of developing other sexually transmitted infections, especially T. vaginalis.

The main manifestation of gonococcal infection in men is urethritis, which can lead to the development of the following complications: prostatitis, vesiculitis, epididymitis, paraurethritis, periurethritis, etc. Infertility may develop.

In women, according to the localization of the inflammatory process, there are:

• Gonococcal infection of the lower parts of the genitourinary system (cervicitis, urethritis, cystitis, vulvovaginitis);
• Inflammatory diseases of the pelvic organs (endometritis, salpingitis, oophoritis, pelvic peritonitis).

In case of chronic process and prolonged course of treatment, ectopic pregnancy and infertility may develop. Gonococcal infection in pregnant women causes premature rupture of membranes, premature birth, and fetal infection.

Other localizations of the lesion (in both men and women):

• Anorectal zone;
• Oropharynx;
• Eye: Gonococcal ophthalmia in newborns, gonococcal conjunctivitis (gonoblenorea) usually occurs in newborns in the first hours or days of life. Infection develops when the fetus passes through the mother's infected birth canal or (in rare cases) comes into contact with the infant's maternity staff with infected hands.

Laboratory diagnostics of diseases caused by Neisseria gonorrhoeae includes direct detection methods such as microscopic examination of stained smear, culture method by inoculation with special means, and pjr (PCR) Diagnosis (detection of pathogen DNA).

Currently, the most common method of diagnosing gonococcal infection remains the method of molecular diagnostics - polymerase chain reaction (PCR). This method allows the identification and appointment of treatment for N. gonorrhoeae in a short time with high diagnostic sensitivity and specificity (more than 96%).

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