Lipoprotein-related phospholipase A2 (Lp-PLA2)

General Information

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent inflammatory biomarker for assessing cardiovascular risk. Phospholipase A2 is a calcium-independent serine lipase synthesized directly in macrophages. The majority of it circulates in the blood bound to low-density lipoproteins (LDL ~80%), and a small portion – together with high-density lipoproteins (HDL ~20%).

Lipoprotein-associated phospholipase A2 can degrade platelet-activating factor (PAF), thereby preventing platelet aggregation and thrombus formation. It also participates in biochemical processes that result in the formation of lysophosphatidylcholine (LPC) and oxidized free fatty acids.

When is the survey conducted?

• Biomarker for assessing the risk of cardiovascular diseases, including stroke
• A marker for assessing the development of kidney disease in patients with diabetes.

Research material - Venous blood

Patient preparation –it is not necessary