Atherogenic Index Laboratory research

This study is conducted only with lipid metabolism

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Atherogenicity index (coefficient) Reflects the ratio of atherogenic lipoproteins (LDL) to the content of antiatherogenic lipoproteins (HDL) in the blood plasma, or more accurately reflects the favorable and unfavorable combination of lipoproteins in terms of the risk of coronary artery disease.

The Plasma Atherogenic Index (AIP) is a strong marker for predicting the risk of atherosclerosis and coronary heart disease.

AIP is related to the particle size of pre- and anti-atherogenic lipoproteins. It is calculated according to the following formula - log (TG / HDL-C). A value of less than 0.11 of AIP is suggested to be associated with a lower risk of cardiovascular disease (CVD); Values ​​between 0.11 and 0.21 and above 0.21 are associated with intermediate and increased risks, respectively.

The atherogenic index correlates with other risk factors for CVD. The most important risk factors are dyslipidemia, hypertension, obesity, physical inactivity, poor diet and smoking. Among them, the plasma lipid profile is a major risk factor for CVD.

Dyslipidemia Is an elevated concentration of lipids (triglycerides (TG)), total cholesterol (TC) and their transporter lipoproteins: HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol) in the blood. It has been scientifically proven that there is a strong correlation between CVD frequency and high levels of LDL-C and low levels of HDL-C; Therefore LDL-C / HDL-C The ratio is often calculated to assess cardiovascular risk. On the other hand, high levels of TG are associated with an increase in LDL-C particles and an increased risk of cardiovascular disease. Based on this, atherogenic dyslipidemia, which is defined as a high LDL-C / HDL-C ratio, and hypertriglyceridemia, is associated with a higher risk of developing cardiovascular disease.

Studies have shown that The increase in the atherogenic index is related to other cardiovascular risk factors; Changes in these risk factors therefore affect the AIP index - lifestyle changes, regular exercise and a healthy diet in turn contribute to a decrease in the atherogenic index.

AIP should be used as an indicator of regular monitoring of CVD in daily practice, especially in individuals who have other cardiovascular risk factors.

When should we take a test for the atherogenic index?

• Risk assessment for ischemic heart disease;
• Diagnosis of hyperlipoproteinemia;
• Atherosclerosis and diseases of the cardiovascular system;
• Liver disease;
• In the ages;
• Obesity;
• arterial hypertension;
• diabetes.

The examination of the atherogenic index is mainly done by examining the following parameters: total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol, and triglycerides.

How to prepare for the test?

Blood sampling is required for analysis (at least 12 hours after the last meal).

Some medications can affect test results, so it is important to consult your doctor and get detailed instructions to prepare for the test.

Research material

Venous blood

Possible interpretation of the results

The atherogenic index (along with LDL and VLDL levels) may increase:

• Hereditary hypercholesterolemia (type IIa);
• Hyperlipoproteinemia II-B and III;
• A diet rich in high cholesterol and saturated fats;
• Hypothyroidism;
• Nephrotic syndrome;
• diabetes;
• Multiple myeloma and other dysgammaglobulinemia;
• Chronic renal failure;
• Porphyria;
• Anorexia nervosa;
• After eating fatty foods;
• Pregnancy.

The atherogenic index (along with LDL and VLDL levels) may decrease:  

• Hypobetalipoproteinemia;
• Hyperthyroidism;
• Chronic anemia;
• Severe hepatocellular diseases;
• Severe stress;
• Inflammatory diseases of the joints;
• Chronic lung disease.

Resources

https://spravochnik.synevo.ua/ru/lipidniy-obmen/lipoproteids-fractions.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715400/