Vitamin K1 | Laboratory research

General Information

Vitamin K1 or phylloquinone belongs to the group of fat-soluble vitamins. Phylloquinone is found in large amounts in green leafy vegetables and some fruits (avocado, kiwi). Vitamin K1 is a necessary cofactor (catalyst) in the process of gamma-carboxylation of protein glutamate (amino acid) residues. Gamma-carboxyglutamic acid obtained by this reaction activates coagulation factors II (prithrombin), VII, IX and X. Other proteins involved in bone metabolism, cell growth, and apoptosis are also affected by gamma-carboxyglutamic acid.

Catabolism (breakdown) of vitamin K takes place in the liver.

Determination of vitamin K from a fasting sample is an indicator of its intake in the diet. The daily dose of vitamin K for women is 90 ng/day, for men 120 ng/day.

Functions of vitamin K in the body:

• Regulation of blood coagulation activity
• Prevention of osteoporosis and bone fractures
• Prevention of calcification of blood vessels
• Prevention of inflammatory and tumor processes

When should we do the research?

When vitamin K deficiency is suspected or symptoms are present.

preliminary preparation –The study is conducted on an empty stomach

Research material -Venous blood

Referral norm –0.13 – 1.19 ng/l

restriction

Certain conditions affect the processes of absorption of vitamin K and, accordingly, the level in the blood. these are:

• Antibiotic therapy (more than 10 days)
• Antiepileptic drugs
• Fat absorption blocking medications and supplements
• Bile acid blocking drugs
• mineral oils
• Preservatives (butylated hydroxytoluene)
• Medicines containing estrogen

Liver and digestive tract diseases