Insulin determination – 2 hours after glucose loading

Possible interpretation of the results

What is the cause of low insulin?

• TypeI Diabetes mellitus:It is the result of an autoaggressive process against pancreatic beta cells
• Diseases of the pancreas:Inflammatory and various degenerative processes of the pancreas may cause clinical manifestations similar to diabetes.
• Surgical removal of the pancreas:Pancreatectomy performed for one or another reason (eg tumor).
• Hypopituitarism:of the pituitary gland Hormonal failure

What causes high insulin levels?

• Insulin resistance:A condition where the cells are not sensitive to insulin, which consequently leads to increased production and release of insulin by the pancreas.
• Obesity:Low insulin levels and excess weight are directly related, as obesity develops as a result of insulin resistance.
• Type II Diabetes mellitus
• Insulinoma:It is a benign tumor of the pancreas that produces insulin.
• Pancreatic cell hyperplasia:Proliferation of normal (non-cancerous) pancreatic cells that produce excess insulin.
• Cushing's syndrome:It is a disease with excessive production of cortisol (hormone of the cortical layer of the adrenal gland), the most common cause of which is pituitary tumor and causes hyperinsulinemia.
• Acromegaly:It is a rare disease caused by an excess of growth hormone (somatotropin) and insulin-like growth factor-1, which provokes excess production of insulin.
• Medicines:Corticosteroids, sulfonylurea drugs (used in the treatment of diabetes), oral contraceptives increase the level of insulin in the blood.