Is it necessary to fast?

Name: Indirect bilirubin
Brand: სინევო
SKU: 774
Price: 13.5 GEL
Availability: InStock
Rating: 5 (1 reviews)

The study is usually conducted without fasting.

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Indirect bilirubin

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Known as: Indirect bilirubin

SKU: 774

Original price was: ₾15.00.Current price is: ₾13.50.

Study material: Venous blood

Response time (working day): 1

The test is done on an empty stomach: Yes

Home call service: Yes

Country: Georgia

Laboratories❯

General Information

Bilirubin

One of the main components of bile, it is formed mainly from hemoglobin in erythrocytes. Other sources of bilirubin are myoglobin, cytochromes, and heme-containing pigments. When hemoglobin breaks down, it is initially formed Free (indirect) bilirubin. Free bilirubin is transported from the spleen to the liver together with albumin. In the liver, it is connected to glucuronic acid - it is conjugated. resulting from Conjugated (direct) bilirubin, which is actively excreted in the bile ducts. Depending on which type of bilirubin concentration increases in the plasma, hyperbilirubinemia is classified as Unconjugated and conjugated.

When should we take the test?

Identify and assess the degree of bilirubinemia;
Differential diagnostics of different types of jaundice;
Liver and biliary tract diseases, hemolytic anemia.

Possible interpretation of the results

Increased concentration of direct bilirubin:

Increased destruction of circulating erythrocytes (hemolytic anemia). Jaundice due to increased pigment production as a result of tissue infarction (pulmonary infarction, accumulation of blood in tissues, after catheterization, rupture of aortic aneurysm);
Some infectious diseases (malaria, septic condition);
Hepatic impairment caused by certain medications;
Impaired bilirubin binding due to low glucuronyltransferase activity:
Neonatal jaundice - Almost all neonates develop transient unconjugated hyperbilirubinemia in the first 2-5 days of life due to the fact that at this stage the liver enzyme glucuronyltransferase is not yet fully formed;
Hereditary glucuronyltransferase deficiency: Gilbert's syndrome, Kriegler-Nayer syndrome (type I glucuronyltransferase deficiency and type II glucuronyltransferase deficiency).

Reference values

Indirect (unconjugated) bilirubinIs a toxic, fat-soluble fraction of total bilirubin that is formed during the breakdown of heme-containing proteins. It accounts for about 75% of total bilirubin. Indirect bilirubin is defined by the difference between total and direct bilirubin values. Its concentration in serum is determined by the rate of penetration of newly synthesized bilirubin into the blood plasma and the rate of bilirubin elimination by the liver (bilirubin liver clearance). The study of indirect (free) bilirubin plays an important role in the diagnostics of hemolytic anemias. The test is also prescribed for the differential diagnostics of hyperbilirubinemia.

How to prepare for the test?

Preferably for the test on empty stomach Presence.

It is recommended to limit alcohol intake, smoking and strenuous physical activity for at least 12 hours before the test.

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Resources

https://spravochnik.synevo.ua/ru/klinicheskaia-himia/bilirubin-frakcionno.html

Total bilirubin

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This medical information is not intended to be a universal treatment guide for all patients. The treatment process, including the type, volume, and frequency of diagnostic tests and therapeutic procedures, is determined by the physician individually — based on an assessment of the patient's condition and relevant medical indications. The decision is made in consultation with the patient. Before purchasing a test, please read the instructions for its preparation.