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HLA-B27 is a protein complex located on the surface of the leukocyte membrane.
The purpose of the test is to determine the presence or absence of the HLA-B27 antigen (protein) to assess the likelihood of an autoimmune disease associated with this marker.
HLA-B27 antigen is detected in 90-95% of patients with clinical and radiological manifestations of ankylosing spondylitis and in 10-20% of patients with only radiological manifestations.
HLA-B27 is a very heterogeneous protein, therefore up to 35 subtypes have been discovered. Subtypes differ from each other in amino acid sequence.
During antigen recognition by T lymphocytes, HLA-B27 plays a dual role:
There is no molecular similarity between HLA-827 and KLEBSLIELLA PNEUMONIAE protein, which may indicate a bacterial pathogenesis of ankylosing spondylitis.
It is possible that antigenic similarity causes a cross-immune response. Autoimmune diseases associated with hla-b27:
Preliminary preparation: not necessary
Study material: Venous blood
in the norm HLA-B27 is negative.
Testing process
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
53 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Kabali village, Dusheti, Kareli, Tianeti.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2024, the Synevo Georgia network will include 3 clinical laboratories and 53 blood sampling units, which will perform more than 300,000 tests.
Contact information
Address: Tsinandali St. N9 (N1 Clinical Hospital area)
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