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₾50.00
Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: YesHepatitis B virus e antigen (HBeAg) determination is a test that is an indicator of the activity of the hepatitis B virus in the body.
The hepatitis B virus E antigen is a small polypeptide that is present in free form in the serum of infected patients in the early stages of hepatitis B virus infection, after the appearance of the S surface antigen. During the phase of active viral replication, the levels of S and E antigens increase rapidly.
At the end of the acute process, the level of E antigen decreases and finally disappears, while at this time antibodies developed against E antigen (anti-HBe) appear. Antibodies against the E antigen remain in the serum for many years, even after the acute process is over.
In hepatitis B virus carriers and patients with chronic hepatitis, a positive E antigen indicates virus replication and an active infectious process. A negative indicator of E antigen means a minimal level or complete absence of virus activity and reproduction.
When evaluating patients with chronic hepatitis B
In the initial diagnostics of HBV infection (in a comprehensive assessment)
Before starting treatment
When monitoring the effectiveness of treatment
In pregnant women with confirmed hepatitis B infection
A positive HBeAg result often indicates:
This is especially important:
A negative HBeAg result means:
The presence of hepatitis B virus E antigen and the absence of HBeantibodies indicate the presence of intensive virus replication (multiplication) and an active infectious process.
The appearance of HBe antibodies in the absence of E antigen indicates the end of the active infectious process. Although the transition to the chronic stage is characterized by the disappearance of antigen and the development of antibodies, the stage of viral shedding may be prolonged.
A negative result for hepatitis B virus E antigen (HBeAg) does not always mean that the virus is no longer replicating. There is so-called HBeAg-negative chronic hepatitis B, when the virus has pre-core/core promoter mutations and is able to actively replicate without producing E antigen. In such cases, quantitative determination of hepatitis B virus DNA is crucial.
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