Hepatitis A virus (HAV) One hundred IgM

General Information

Hepatitis A virus is a small, non-encapsulated virus that belongs to the Picornavirus family and the Hepatovirus genus. It is represented by a single-stranded RNA genome and a capsid.

The virus is mainly transmitted through the fecal-oral route, through contaminated water and food.

The incubation period of the disease is up to 28 days (on average 15-60 days). Developed hepatitis is of moderate severity, although complications may develop. Hepatitis A virus does not persist in the body and does not give a chronic form.

The virus is present in the blood and feces 2 weeks before the clinical development of the disease and 2 weeks after the onset of jaundice.

Routine diagnostics of infection is based on serology. The first antibodies that appear in the blood immediately after the development of ARIS anti-HAV-IgM symptoms reach a maximum in one month and reverse in 6 months. IgG appears about 2 weeks after the acute period. The presence of IgG confirms past infection or the presence of immunity to hepatitis A.

When is the test conducted?

Diagnosis of infection caused by hepatitis A virus. To detect an acute form or transferred infection.

Patient preparation –The study is conducted on an empty stomach

Research material - Venous blood

Referral norms – IgM, IgG - negative

A positive indicator of anti-HAV-antibodies does not exclude the presence of other hepatitis viruses, especially hepatitis B viruses.

The level of anti-HAV-antibodies is affected by such circumstances as:

• Treatment with high doses of biotin. It is recommended to conduct a study 8 weeks after the end of the biotin course.
• High titer of anti-streptavidin and anti-ruthenium antibodies
• Monoclonal antibody therapy.