Country: Georgia
Laboratories❯
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Original price was: ₾49.00.₾44.10Current price is: ₾44.10.
Study material: Venous blood
Response time (working day): 1
The test is done on an empty stomach: Yes
Home call service: YesHaptoglobin is a protein that belongs to the fraction of alpha-2-globulins. Haptoglobin exhibits high affinity for free (released from erythrocytes) hemoglobin, binds to it and inhibits harmful oxidative activity.
From the structural point of view, serum haptoglobin is a tetrameric glycoprotein, which consists of 2 pairs of alpha and beta chains connected by a disulfide bond. Its synthesis is mainly carried out in the liver and is regulated by interleukins IL-6 and IL-1.
The haptoglobin-hemoglobin complex is easily removed from the circulation by the reticulo-endothelial system (liver, spleen), as a result of which it is metabolized into free amino acids and iron. This is an effective method of maintaining iron in the body.
A decrease in the serum haptoglobin level, under normal liver function, is usually associated with intravascular hemolysis, that is, the more active and prolonged the hemolysis, the lower the serum haptoglobin concentration.
A decrease in the level of haptoglobin (along with hypoalbuminemia, polyclonal hypergammaglobulinemia, and a decrease in the level of other alpha-2-globulins) in liver diseases indicates an unfavorable prognosis.
In addition to binding to free hemoglobin, haptoglobin binds to granulocytes, monocytes, and lymphocytes, thereby exhibiting immunomodulatory activity.
The study is conducted to diagnose hemolytic conditions
Preparation of the patient:The study is conducted on an empty stomach. It is recommended to limit physical activity before taking a blood sample
Material for examination:Venous blood
Reference norms –30-200 mg/dL (0.3-2 g/dL) (3-20 nmol/L)
| An increase in haptoglobin is characterized by: | Reduction of haptoglobin is characterized by: |
| • Acute and chronic infections and inflammatory processes • Neoplasias, lymphomas - in an advanced stage • Suppression of bile ducts • Collagenoses • Pathologies with tissue breakdown | Acquired diseases • Intravascular hemolysis, of various etiology • Autoimmune hemolytic anemia • Complications associated with bacterial endocarditis or prosthetic heart valves • Transfusion reactions • Fetal erythroblastosis • Malaria • Nocturnal paroxysmal hemoglobinuria • Tissue hematomas • Thrombotic thrombocytopenic purpura • Drug-induced hemolytic anemia • Acute and chronic liver diseases Congenital diseases • G6PD and pyruvate kinase deficiency • Hereditary spherocytosis • Thalassemia • Megaloblastic anemias • Genetic absence of haptoglobin |
During treatment with corticosteroids or some inflammatory diseases, getting a normal haptoglobin level does not exclude hemolysis!
Testing process
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| Purchase a test | Submission of material |
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| Results Online | Consult a doctor |
