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Glycated Hemoglobin (HbA1c) Is hemoglobin in which the glucose molecule condenses with the β-terminal valine (amino acid) of the β-chain of the hemoglobin molecule. Glycosylated hemoglobin represents a small percentage of hemoglobin (5-7%). It is the result of continuous and irreversible binding of glucose from the blood throughout the life of erythrocytes (approximately 100-120 days). Glycosylation occurs in two stages, through non-enzymatic reactions, depending on the level of glucose in the blood. The increase in glycated hemoglobin level is proportional to the average blood glucose concentration in the last 2-3 months before testing; Its level in the blood normalizes 4-6 weeks after the onset of euglycemia.
Increase in glycated hemoglobin concentration:
Decreased glycated hemoglobin concentration:
The HbA1C test is used for screening, diagnostics, and long-term monitoring of glucose levels in patients with diabetes. It also plays a prognostic role in determining the risk of macro- and microvascular complications of diabetes.
Since 2010, a recommendation from the ADA (American Diabetes Association) has been used to diagnose glycated hemoglobin HbA1c with a threshold value of 6,5% or more for the diagnostics of diabetes.
Advantages of studying glycated hemoglobin (HbA1c) for the diagnostics of diabetes and prediabetes:
No specific training is required.
It is recommended to limit alcohol intake, smoking and strenuous physical activity for at least 12 hours before the test.
Testing process
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Purchase a test |
Submission of material |
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Results Online |
Consult a doctor |