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Glucagon is a peptide hormone consisting of 29 amino acids, which is synthesized by the alpha islet cells of the pancreas and the hypothalamus.
The function of hypothalamic glucagon is not fully understood.
Pancreatic glucagon is involved in carbohydrate metabolism. Its function is the opposite of insulin: it is stimulated in hypoglycemic conditions and causes an increase in blood sugar levels. The hyperglycemic effect of glucagon is carried out in the liver through glycogenolysis (glycogen breakdown) and gluconeogenesis (glucose synthesis). After regulation of blood sugar concentration, glucagon is inactivated.
Glucagon metabolism is influenced by the functional state of the kidneys. In kidney failure, a high fasting glucagon level is observed.
Excess secretion of glucagon causes hyperglycemia. When the blood glucose concentration is regulated by insulin therapy, the glucagon level also returns to normal.
Glucagonomas are rare tumors of the pancreas that develop from the cells of the islets of Langerhans and produce glucagon. Causes symptoms of diabetes, diarrhea, erythema.
Glucagon levels are elevated in carcinoid tumors, hepatocellular carcinomas, and other neuroendocrine tumors.
Decreased or absent glucagon levels are sometimes found in type I diabetes. Glucagon deficiency is associated with loss of pancreatic tissue.
Determination of glucagon is used in the diagnostics of glucagon-producing tumors and diabetic patients.
Patient preparation – The study is conducted on an empty stomach. It is recommended to abstain from food and stressful factors for 8 hours before the research.
Reference norm: < 209 ng/l
Increase in glucagon levels It is noted in the following situations:
Low levels of glucagon are noted in the following situations:
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
53 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Kabali village, Dusheti, Kareli, Tianeti.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2024, the Synevo Georgia network will include 3 clinical laboratories and 53 blood sampling units, which will perform more than 300,000 tests.
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