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Free β-chorionic gonadotropic hormone

Known as: Free β-chorionic gonadotropin hormone
SKU: 276


Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: Yes
Country: Georgia

General Information

Human chorionic gonadotropin (hCG) Is a glycoprotein hormone that is normally found in the blood and urine only during pregnancy. It is synthesized by placental tissue (starting with primitive trophoblasts) and prevents corpus luteum destruction in the first weeks of pregnancy. hCG or hCG-like substances are also produced by various trophoblastic or non-trophoblastic tumors.

Intact hCG consists of 2 subunits (alpha and beta subunits) that are linked by a noncovalent bond. These subunits can also be represented in a free, unrelated form. The alpha subunit has the identical structure of the homologous subunit of pituitary glycoprotein hormones (LH, FSH, and TSH). Beta subunits are specific for each of these hormones, which determines their specific biological activity. However, there are similarities between the beta subunits of hCG and LH, which explains the substantially identical biological activity of these two hormones.

hCG-free β-subunit fraction Represents about 1% of total intact hCG, it is biologically inactive. Studies have shown that the level of free fraction of the β-subunit of hCG is the most accurate marker of the presence of fetal aneuploidy in the first trimester of pregnancy.

When should we take the test?

  • Diagnosis and monitoring of trophoblastic diseases (molar pregnancy, choriocarcinoma);
  • Testicular, hCG secreting, tumor diagnostics and monitoring with increased free beta-hCG / hCG ratio (in some cases the tumor secretes only free beta-hCG);
  • Early monitoring of in vitro fertilization results;
  • Determination of free beta-hCG in maternal serum in combination with PAPP-A (pregnancy-associated plasma protein) is useful for prenatal screening for Down syndrome, trisomy 18, and other fetal chromosomal abnormalities in the first trimester of pregnancy (double test);
  • Determination of free beta-hCG in maternal serum in combination with AFP and unconjugated estriol is useful for prenatal screening for Down syndrome, trisomy 18, neural tube defects, and other disorders in the second trimester of pregnancy (triple test).

Possible interpretation of the results

Free beta-hCG concentration increases:

  • Trisomy 21 (Down syndrome);
  • Shereshevsky-Turner syndrome;
  • Multiple pregnancies;
  • Cystic drift, chorionic carcinoma;
  • A mother with diabetes;
  • Taking synthetic progestogens.

Free beta-hCG concentration decreases:

  • Trisomy 13 (Pataus syndrome), Trisomy 18 (Edwards syndrome);
  • Anencephaly;
  • External pregnancy of the uterus;
  • Risk of termination of pregnancy, intrauterine death of the fetus;
  • Preeclampsia.

Additional information

How to prepare for the test?

No special preparation is required for the test.

The patient should indicate the date of the last menstrual period or the gestational age determined by the ultrasound.

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Free Beta-HCG




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