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Fibrinogen | Laboratory research

Name: Fibrinogen | Laboratory research
Brand: სინევო
SKU: 1103
Price: 18 GEL
Availability: InStock
Rating: 5 (1 reviews)

Known as: fibrinogen Laboratory research

SKU: 1103

Original price was: ₾20.00.Current price is: ₾18.00.

Research material: blood

Response time (working day): 1

The test is done on an empty stomach: Yes

Home call service: Yes

Country: Georgia

Laboratories❯

General Information

Fibrinogen (Factor I) - Glycoprotein, which is a precursor of fibrin, and fibrin, in turn, forms the basis of thrombus. Fibrinogen is the first factor in the blood coagulation system. Blood plasma contains it at a concentration of 200-400 mg / dl (254 g / l). It is synthesized in the liver at a rate of 1,75-5,0 g / day. The half-life is 3-5 days.

When should we take the test?

Prognosis of the development of cardiovascular diseases, assessment of the risk of thrombotic complications (with lipid profile, CRP, homocysteine);
Assessment of the activity of the inflammatory process;
Assessment of hemostasis disorders (bleeding or thrombosis);
Preoperative examination and postoperative period;
Examination during pregnancy in different trimesters;
Congenital or acquired fibrinogen deficiency (A- / hypo- / dysfibrinogenemia);
Monitoring of thrombolytic therapy.

Possible interpretation of the results

Fibrinogen levels increase:

Inflammatory infectious diseases;
Cardiovascular diseases;
Atherosclerosis;
Subacute, chronic disseminated intravascular coagulation syndrome;
Surgical interventions, injuries, burns;
Collagenoses;
Kidney disease (pyelonephritis, glomerulonephritis, HUS, nephrotic syndrome);
Neoplasms;
smoke.

Fibrinogen levels decrease:

DIC syndrome;
Congenital dysfibrinogenemia;
Due to immaturity of the hemostatic system in newborns;
Severe liver damage (cirrhosis, toxic or food poisoning);
Thrombolytic therapy.

Product description

In addition to coagulation, fibrinogen also participates in fibrinolytic reactions: it binds to excess thrombin (hence it is also called antithrombin I) and activates plasminogen. In this regard, changes in the amount and / or structure of fibrinogen can cause both bleeding and thrombosis.

In addition, fibrinogen belongs to the group of proteins of the acute phase - its increase is observed after 24-48 hours, which leads to an increase in erythrocyte sedimentation rate (fibrinogen is the main protein that affects the rate of EDS). In addition to participating in inflammation, fibrinogen also plays an important role in the processes of angiogenesis. In the formation of atherosclerotic plaques, fibrinogen levels are a prognostic marker in the case of cardiovascular disease.

Plasmin removes fibrinogen as well as fibrin. The action of plasmin on fibrinogen produces fragments X, Y, D and E. Similar fragments are released after fibrin breakdown, as well as D-dimers and other degradation products that have cross-covalent bonds.

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