Country: Georgia
Laboratories❯
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Original price was: ₾43.00.₾38.70Current price is: ₾38.70.
Study material: Venous blood
Response time (working day): 1-2
The test is done on an empty stomach: Yes
Home call service: YesEstradiol (E2) It is the most biologically active estrogen.
Estrogens are involved in the development of female secondary sexual characteristics and, together with progesterone, are responsible for regulating the menstrual cycle, developing female genitalia, and maintaining pregnancy.
It affects calcium metabolism and has a positive effect on bone mass. Low estrogen levels lead to decreased bone mineralization, which increases the risk of fractures and postmenopausal osteoporosis.
In men: Infertility, disorders of the hypothalamic-pituitary-gonadal system, gynecomastia and tumor of the testicles, hyperplasia of the adrenal cortex, osteoporosis.
In women: Infertility, disorders of the hypothalamic-pituitary-gonadal system, gynecomastia and ovarian tumors, hyperplasia of the adrenal cortex. Ovulation monitoring in stimulation cycles (in vitro fertilization), osteoporosis.
High estradiol levels can be manifested by menstrual irregularities, headaches, bloating, fatigue, chest pain, and mood swings.
Low estradiol levels are associated with irregular or non-regular menstruation, frequent urinary tract infections, pain during intercourse due to vaginal dryness, mood swings, depression, fatigue and so-called "flares".
Increases in estradiol levels may be caused by:
Decreased estradiol levels may be caused by:
Estradiol is produced mainly by the ovaries (follicle cells, corpus luteum), but small amounts are also produced in the adrenal cortex. During pregnancy, it is synthesized mainly by the placenta. Estradiol secretion has two peaks during the menstrual cycle. Its level increases during the follicular phase and depends on the growth and development of the ovarian follicle. It grows until the moment of ovulation and again, when a yellow body is formed. At the end of the menstrual cycle, estradiol and estrogen levels decrease.
In men, estradiol is produced by the testicles and adrenal glands. Its levels may increase in cases of impotence, some tumors, as well as in cases of excessive use of marijuana, alcohol or drugs (phenothiazines and spironolactone).
It is recommended to take the material in the first half of the day, in a calm state. Fatty foods and medications and products containing biotin (vitamin B7) should be excluded one day before the examination.
The patient should indicate the date of the last menstrual period (6-7 days of the menstrual cycle is recommended) or the gestational age determined by ultrasound.
Some medications act on estradiol levels: clomiphene, diazepam increase rates; Oral contraceptives, Megestrol reduces its levels.
Venous blood
When monitoring fertility, it is advisable to perform several tests over several days to determine basal estradiol levels and "peaks." Low basal levels without "peaks" or persistently elevated hormone levels are a sign of an anovulatory cycle (cycles without ovulation).
Low levels of estradiol in women over the age of 40 can be a sign of premature menopause, known as premenopause. In young women, low estradiol levels may be associated with anorexia, chronic kidney disease, or premature ovarian failure.
Higher levels of estradiol during pregnancy are also noted due to its increased production by the placenta.
Testing process
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