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Endomysium is the inner connective tissue sheath of the smooth muscle fibers of the gastrointestinal tract, which separates the muscle fibers from each other. Antibodies against its proteins are produced during celiac disease, during immune inflammation in the tissue of the intestinal wall, so the determination of endomysium antibodies is an important diagnostic criterion for celiac disease.
IgA anti-endomysium antibodies are found in 90% of celiac patients. The sensitivity and specificity of the study is 98%.
A positive test result confirms the diagnostics of celiac disease, but additional tests may be needed to detect intestinal damage.
Recurrent abdominal pain and bloating
during chronic diarrhea
during constipation
In intestinal flatulence
while losing weight
In case of frequent stomatitis
Expressed in general general weakness
during anemia
During depression and other mood swings
In the presence of rashes and itching on the skin
Bone and joint pain
Symptoms in children may also include:
Vomiting
Irritability
growth retardation
weight loss
Damage to tooth enamel
Sometimes there is a need for additional studies, such as:
Determination of tissue transglutaminase antibodies
Antibodies to deaminated gliadin peptidase
General blood test
Determination of cholesterol
Thyroid functions
Sometimes a total IgA determination is needed to detect its deficiency. In general IgA deficiency, the endomysial antibody test is false negative and other tests are needed to confirm celiac disease.
A venous blood sample is used
Special preparation
3-4 weeks before the research, the patient should start taking gluten-containing products, otherwise the antibody test will be ineffective.
Testing process
| Purchase a test | Submission of material |
| Results Online | Consult a doctor |
