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Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: YesDouble Test is a first-trimester screening test that assesses the risk of chromosomal abnormalities in the fetus, including Down syndrome (trisomy 21) and Edwards syndrome (trisomy 18).
The test involves measuring two biochemical markers in the mother's blood—free β-hCG and PAPP-A. The test is usually performed between 11–13 weeks and 6 days of pregnancy.
The obtained results are processed by a special computer program. It has fetal chromosomal abnormalities - Chromosome 21 (Down Syndrome), I-Chromosome 13 (Pataus Syndrome), Chromosome 18 (Edwards Syndrome) და Nerve stem defect Of existence Allows risk assessment.
The first trimester of pregnancy or a double test of pregnancy Held at 11-13 weeks. As a result, the concentration of two hormones in the blood of a pregnant woman - Free chorionic gonadotropin (β-hCG)და Pregnancy-associated blood plasma protein A (PAPP-A) Will be determined. To perform the test, the ultrasound examination determines the size of the fetal coccyx, the thickness of the neck crease and the size of the nasal bone.
A double test is required Venous blood.
A double test is recommended for all pregnant women at 11-13 weeks. Tests are especially important if the following factors are present:
Low risk:The risk data calculated at this time are less than the set limit.
Low risk does not completely rule out the presence of Down syndrome, trisomy 18 or 13.
Increased risk:The calculated risk data exceeds the set limit. The "increased risk" obtained is not a confirmed diagnostics of trisomy 21, 18, or 13, but requires further investigation.
The first trimester biochemical screening (double) test includes:
PAPP-A (Pregnancy-Related Plasma Protein) A glycoprotein derived from the placenta. During pregnancy, it is produced in large quantities by trophoblasts and enters the maternal circulation. Serum levels of this protein increase with gestational age, reaching a peak at the end of pregnancy.
Decreased PAPP-A concentration during pregnancy is associated with fetal chromosomal abnormalities: trisomy 21, 18, 13, Turner syndrome, paternal triploidy (minor decrease), maternal triploidy (significant decrease).
In the first trimester of pregnancy Β subunit of free chorionic gonadotropin (β-hCG) - is considered a more relevant marker than the intact HCG molecule. Β-hCG level in pregnant women with Down syndrome> 2 MoM. The rates are also much higher for triploids of paternal origin. Free β-hCG levels are normal in Turner syndrome. In the presence of trisomy 18 or 13 as well as maternal triploid, the concentration of free β-hCG is significantly lower.
The double test is not a diagnostic method. In the event of an increased risk of fetal anomaly, the obstetrician-gynecologist will decide whether to perform an additional examination: biopsy of the chorionic villus (I trimester) or amniocentesis (II trimester) and further cytogenetic examination.
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Testing process
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| Purchase a test | Submission of material |
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| Results Online | Consult a doctor |
