Diamino oxidase | Laboratory research

General Information

diamine oxidase (DAO) It is one of the important enzymes that participates in the breakdown of histamine received with food, that is, it is a natural mechanism of protection against histamine.

Diamine oxidase is synthesized in the small intestine. Certain foods, medications, or supplements can inhibit this process.

A hypersensitivity reaction develops if the level of histamine received from the environment (in the form of food) or produced in the body exceeds the activity of diamine oxidase.

Diamine oxidase deficiency Associated with the development of such symptoms and pathological conditions as:

Migraine and other types of headache

Dizziness, nausea, vomiting

Chronic fatigue syndrome

Skin rash, eczema, psoriasis symptoms, urticaria

Swelling of the nasal mucosa, asthma, bronchospasm

Gastrointestinal disorders, irritable bowel syndrome, diarrhea, flatulence, spasmodic abdominal pain

Dysmenorrhea, premenstrual syndrome, estrogen dominance

Arrhythmia, hyper or hypotension

Anaphylaxis

Fibromyalgia

Violation of the day-night circadian rhythm

Violation of body temperature regulation, memory and thinking problems

Mood disorders, anxiety or depression

The symptoms of diamine oxidase deficiency are similar to those caused by histamine excess (because diamine oxidase is involved in the metabolism and breakdown of histamine).

Patients with Crohn's disease, urticaria, celiac disease, and others have low blood levels of diamine oxidase.

The association of diamine oxidase deficiency with allergic rhinitis is important. Allergic rhinitis is caused by immune inflammation caused by contact with an antigen. Histamine is the main mediator that causes the development of the immune reaction and related symptoms.

Since diamine oxidase is synthesized in the gastrointestinal system, its low serum level is an indicator of gastrointestinal dysfunction.

The determination of diamine oxidase in serum is important for the diagnostics of impaired tolerance to histamine.

Under normal conditions, diamine oxidase forms an enzyme barrier in the cells of the small intestine, which is an additional protective mechanism to avoid resorption of histamine received with food.

which foods increase histamine activity?

There are a number of products that contain histamine or participate in its release processes. these are:

Alcoholic drinks, especially red and sparkling wines

cheese

Sausages (salami, ham, chorizo)

Fish, seafood and sauces

Vegetables - eggplant, tomato, spinach

Fruits - strawberries, bananas, pineapples

chocolate

etc

Medicines that reduce the activity of diamine oxidase:

Analgesics

Anti-histamines

diuretics

Antibiotics

Antiarrhythmic

anti-asthma

Mucolytics

Antidepressants

Antirheumatoid drugs

Tranquilizers

When histamine accumulates in the body due to diamine oxidase deficiency, symptoms associated with histamine excess occur.

The diamine oxidase test is a diagnostic tool for evaluating its activity in serum.

Diamine oxidase activity is lower in women than in men.
During pregnancy, the concentration of diamine oxidase can increase up to 500 times, because it is also synthesized by the placenta. This can explain, for example, migraine remission in pregnant women.

Study material: Venous blood

The study is conducted on an empty stomach

It is recommended to stop taking drugs that inhibit diamine oxidase synthesis at least 8 hours before the study.