Desmoglein-3 autoantibodies (serum)

General Information

Desmoglein 1 and desmoglein 3 are adhesion glycoproteins that form the junctions between cells and are the main target of autoantibodies in the pathogenesis of the disease. Pemphigus At the time.

Pemphigus is an autoimmune skin disease in which desmoglein 1 and desmoglein 3 antibodies develop. The disease is characterized by blistering of the skin. “Leafy” pemphigus affects the superficial layers of the skin. At this time, desmoglein 1 antibodies develop predominantly. In pemphigus vulgaris, the skin is damaged to much deeper layers. This form of the disease is characterized by skin erosions and blisters. Desmoglein 3 antibodies are more characteristic of pemphigus vulgaris.

Studies have confirmed that pemphigus diagnostics is determined by the presence or absence of desmoglein 1 and 3 antibodies. According to the type of antibodies, the diagnostics of foliar or bullous (vulgar) pemphigus is made.

Determination of desmoglein 3 autoantibodies is a screening test for the diagnostics of pemphigus.

Research material  – Venous blood

Reference boundaries

Desmoglein 1
<14.0 is one of the worst
14.0-20.0 unambiguous answer
>20.0 one - positive

Desmoglein 3
<9.0 one – negative
9.0-20.0 unambiguous answer
>20.0 one - positive