Desmoglein 1 | Autoantibodies (serum)

General Information

Desmoglein 1 and desmoglein 3 are adhesive (binding) glycoproteins of desmosomes, which provide a close connection between the cells. Desmoglein 1 and desmoglein 3 are tissue targets against which autoantibodies develop in disease. Pemphigus At the time.

Pemphigus is an autoimmune skin disease in which desmoglein 1 and desmoglein 3 antibodies develop. The disease is characterized by blistering lesions of the skin. "Foliar" pemphigus affects the superficial layers of the skin. At this time, mainly desmoglein 1 antibodies develop. In pemphigus vulgaris, the skin is damaged to much deeper layers. This form of the disease is characterized by skin erosions and blisters. Desmoglein 3 antibodies are highly characteristic of pemphigus vulgaris.

Studies have confirmed that pemphigus diagnostics is determined by the presence or absence of desmoglein 1 and 3 antibodies. According to the type of antibodies, the diagnostics of foliar or bullous (vulgar) pemphigus is made.

Research material  – Venous blood

Reference boundaries

Desmoglein 1
<14.0 is one of the worst
14.0-20.0 unambiguous answer
>20.0 one - positive

Desmoglein 3
<9.0 one – negative
9.0-20.0 unambiguous answer
>20.0 one - positive