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₾125.00
Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: Yes
Home call service: Yes
Cytokeratin fragment 19 antigen (CYFRA 21-1) belongs to the cytokeratin protein family, which is mainly synthesized in epithelial tissue and forms the cytoskeleton of epithelial cells.
CYFRA 21-1 is used as a tumor marker, especially in non-small cell lung cancer, along with carcinoembryonic and squamous cell antigens. Also for other epithelial tumors such as bladder carcinoma. An increase in its concentration during a tumor is associated with cell lysis (breakdown), after which cytokeratin degradation products are released into the blood.
Like other tumor markers, cytokeratin fragment 19 has less screening and diagnostic value; it is used to assess the progress of treatment and prognosis of the disease.
CYFRA 21-1 is a relatively new marker defined by 2 monoclonal antibodies directed against cytokeratin fragment 19.
Preliminary preparation: no need
Material for examination:Venous blood
Reference norms:<3.3 ng/ml
CYFRA 21-1 is not used for lung cancer screening in asymptomatic patients or in high-risk groups (eg smokers).
Since cytokeratin 19 is not an organ-specific marker, its level can also be increased in other volumetric processes.
Factors that may cause inaccuracy of answers:
Immunohistochemical studies have confirmed that cytokeratin 19 is mainly found in lung carcinomas, so it is used as a marker of non-small cell lung cancer.
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