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Creatinine | Laboratory research

Known as: Creatinine | Laboratory research
SKU: 1055

Original price was: ₾18.00.Current price is: ₾16.20.

Study material: Venous blood
Response time (working day): 1
The test is done on an empty stomach: Yes
Home call service: Yes
Country: Georgia

General Information

Creatinine It is a chemical substance that is produced in the muscles during the process of energy production (as a result of the breakdown of creatine). It is constantly released into the blood and excreted by the kidneys.

Creatinine is excreted by the kidneys. Impaired renal function decreases creatinine secretion, leading to an increase in serum creatinine levels. Thus, the creatinine concentration correlates with the glomerular filtration rate and therefore the main benefit of determining its concentration is the diagnostics of renal failure.

When should we take the test?

  • In asymptomatic patients
  • During pregnancy
  • In symptomatic patients who have:
  • Symptoms associated with urination
  • Hypertension
  • Acute and chronic kidney disease
  • Extrarenal disease with diarrhea
  • Vomiting
  • Abundant sweating
  • Acute disease
  • Postoperative period
  • The need for intensive medical care
  • Sepsis
  • Shock
  • Polytrauma
  • Hemodialysis
  • Metabolic diseases (diabetes, hyperuricemia)
  • Diseases with impaired protein metabolism (multiple myeloma, acromegaly)
  • Treatment with nephrotoxic drugs

Possible interpretation of the results

Creatinine increases

  • Acute or chronic glomerular or tubulo-interstitial cause of the kidney;
  • Urinary tract obstruction (postrenal azotemia);
  • Decreased renal perfusion (prerenal azotemia): congestive heart failure, shock, dehydration;
  • Musculoskeletal disorders: myasthenia gravis, muscular dystrophies, poliomyelitis; Rhabdomyolysis;
  • Hyperthyroidism;
  • Gigantism, acromegaly.

Creatinine decreases

  • Pregnancy (normal values: 0,4-0,6 mg / dL; levels above 0,8 mg / dL are considered abnormal and require additional examination);
  • Decrease in muscle mass;
  • Protein deficiency in the ration;
  • Severe liver disease.

Reference values

Material for examination: Venous blood

 

  • It is advisable to do the test on empty stomach .
  • It is necessary to inform the laboratory about the medications the patient is taking - cimetidine, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, ibuprofen, chemotherapy drugs, cephalosporins, and others.
  • It is recommended to abstain from meat for 12-24 hours before the test.
  • Alcohol, tobacco, and alcohol should be excluded for 12 hours before the study.
  • In the morning, before blood collection, you can drink water.

Higher creatinine levels are found in men and people with large muscle mass.

The same creatinine concentration in young and old does not mean the same glomerular filtration rate (creatinine clearance (excretion) decreases in the elderly, but creatinine production also decreases)

Serum creatinine is a more specific and sensitive indicator of renal function than urea. However, in chronic kidney disease, it is useful to determine both creatinine and serum urea (BUN (Blood Urea Nitrogen) - with the urea nitrogen parameter), as the BUN / creatinine ratio (norm - 10-20) provides more information about renal function.

Testing process

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This medical information is not intended to be a universal treatment guide for all patients. The treatment process, including the type, volume, and frequency of diagnostic tests and therapeutic procedures, is determined by the physician individually — based on an assessment of the patient's condition and relevant medical indications. The decision is made in consultation with the patient. Before purchasing a test, please read the instructions for its preparation.
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