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Creatinine It is a chemical substance that is produced in the muscles during the process of energy production (as a result of the breakdown of creatine). It is constantly released into the blood and excreted by the kidneys.
Creatinine is excreted by the kidneys. Impaired renal function decreases creatinine secretion, leading to an increase in serum creatinine levels. Thus, the creatinine concentration correlates with the glomerular filtration rate and therefore the main benefit of determining its concentration is the diagnostics of renal failure.
Creatinine increases
Creatinine decreases
Material for examination: Venous blood
Higher creatinine levels are found in men and people with large muscle mass.
The same creatinine concentration in young and old does not mean the same glomerular filtration rate (creatinine clearance (excretion) decreases in the elderly, but creatinine production also decreases)
Serum creatinine is a more specific and sensitive indicator of renal function than urea. However, in chronic kidney disease, it is useful to determine both creatinine and serum urea (BUN (Blood Urea Nitrogen) - with the urea nitrogen parameter), as the BUN / creatinine ratio (norm - 10-20) provides more information about renal function.
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