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Cotinine - a metabolite of nicotine (serum)

Also known as: nicotine metabolites
SKU: 1540

255.00

Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: Yes
Country: EU

General Information

Cotinine is a major metabolite of nicotine that is produced in the body after tobacco use or exposure to nicotine. Its measurement is used to assess active and passive smoking, as well as to monitor smoking cessation and nicotine dependence.

Cotinine

Nicotine It is a substance found in the leaves of tobacco and some other plants that can easily lead to addiction.

Cotinine Cotinine is an alkaloid produced in the body as a result of the metabolism (transformation) of nicotine. Cotinine remains in the body longer than nicotine, therefore, its determination is used to detect the content of tobacco products in the blood.

 

Nicotine intoxication may be accompanied by the following symptoms:

  • Circulatory abdominal pain
  • Restlessness and anxiety
  • Burning sensation in the mouth
  • Nausea-vomiting
  • Changes in breathing and heart rate
  • Dizziness, headache, dizziness
  • muscle weakness

 

Material for examination:Venous blood

Reference limits: Negative

When should we take the test?

Research is underway on cotinine, to confirm nicotine consumption or exposure to tobacco smoke. Cotinine is the main metabolite of nicotine and remains in the body longer than nicotine itself.

The study is prescribed:

  • For the assessment of active or passive smoking
  • To control e-cigarette/vaping use
  • For monitoring smoking cessation programs
  • When nicotine intoxication is suspected
  • In pre-operative or prophylactic evaluation
  • During insurance or professional screening
  • To assess exposure to tobacco smoke in children or non-smokers.

Possible interpretation of the results

Cotinine levels in the blood reflect the intensity of nicotine intake and exposure to tobacco smoke. Low or absent levels typically indicate non-smoking status, while elevated levels correspond to active smoking, e-cigarette use, or passive smoking.

When interpreting the results, it is important to consider:

  • History of active and passive smoking
  • Use of nicotine-containing products
  • Electronic cigarette/vape
  • Nicotine replacement therapy (patch, gum, etc.)

Reference values

Cotinine has an average half-life of 16–20 hours, making it a relatively reliable biomarker of nicotine exposure.

 

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This medical information is not intended to be a universal treatment guide for all patients. The treatment process, including the type, volume, and frequency of diagnostic tests and therapeutic procedures, is determined by the physician individually — based on an assessment of the patient's condition and relevant medical indications. The decision is made in consultation with the patient. Before purchasing a test, please read the instructions for its preparation.
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