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Arginine-vasopressin (AVP) and copeptin are derived from the same precursor peptide, preprovasopressin, along with neurophysin II and vasopressin. Copeptin is released together with vasopressin from the magno and parvocellular neurons of the hypothalamus during the conversion of the precursor protein.
Copeptin is much more stable in plasma than arginine-vasopressin, so it is used to detect water-electrolyte imbalance. Both copeptin and arginine-vasopressin are sensitive to osmotic stimuli and their concentrations increase in response to body water deficit.
In diabetes insipidus, the ability to concentrate urine in response to osmotic stimuli is impaired.
The main cause of central diabetes insipidus is a decrease in arginine-vasopressin production. Nephrogenic diabetes insipidus is caused by decreased renal response to arginine-vasopressin.
Determination of plasma copeptin is essential for the diagnostics of arginine-vasopressin-related disorders. Determination of copeptin is also provided in case of violation of antidiuretic hormone secretion.
Copeptin is also a marker of acute hemodynamic stress. It is important to diagnose cardiac disorders such as acute coronary syndrome, stable coronary artery disease (stable angina), congestive heart failure, and acute ischemic stroke.
Biomarker of polyuria-polydipsia
Because copeptin corresponds to and reflects the amount of vasopressin in the circulation, it is a biomarker for conditions such as polydipsia-polyuria (increased thirst, frequent urination) and hyponatremia (decreased sodium concentration in the blood). These symptoms are clinical manifestations of central diabetes insipidus, nephrogenic diabetes insipidus and primary polydipsia.
Material for examination: Venous blood
Research method: Immunofluorescence study
Reference norms:
depends on the osmolar pressure
270 – 280 mosmol < 11,6 kg pmol/l
281 - 285 mosmol - 1,0 - 13,7 kg pmol/l
286 - 290 mosmol - 1,5 - 15,3 kg pmol/l
291 - 295 mosmol - 2,3 - 24,5 kg pmol/l
296 - 300 mosmol - 2,4 - 28,2 kg pmol/l
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
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30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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