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Complete coagulation (APTT, PT, INR, fibrinogen)

Name: Complete coagulation (APTT, PT, INR, fibrinogen)
Brand: სინევო
SKU: 283
Price: 40.5 GEL
Availability: InStock
Rating: 5 (1 reviews)

Synevo editorial team

Known as: Complete coagulogram

SKU: 283

Original price was: ₾45.00.Current price is: ₾40.50.

Study material: Venous blood

Response time (working day): 1

The test is done on an empty stomach: Yes

Home call service: Yes

Country: Georgia

Laboratories❯

General Information

Coagulation Is an ongoing process in the body that prevents excessive bleeding. However, the circulating blood in your blood vessels should not normally clot. In the event of a clot and blood clot (s), a blood clot can travel through your bloodstream to the heart, lungs, or brain, causing a heart attack, stroke, or even death.

Coagulation tests determine the ability of a blood to clot and the time it takes to clot. Testing will help your doctor assess the risk of developing excessive bleeding or thrombosis.

When should we take the test?

aPTT

Control and monitoring of therapy with non-fractional heparin and thrombin inhibitors (hirudin, argatroban).
Diagnosis of congenital or acquired failure of certain coagulation factors (XII, XI, IX, VIII, VII), suspicion of hemophilia or von Willebrand disease.
Determine the presence of specific or nonspecific coagulation inhibitors (lupus anticoagulant, antiphospholipid antibodies).

PT

Evaluation of the activity of vitamin K-dependent coagulation factors.
Suspected congenital deficiency of coagulation factors (hereditary hemophilia and II, V, VII, X and fibrinogen factors).
Monitoring treatment with anticoagulants (syndrome, etc.).
Monitor liver function (assess its protein-producing function) and detect its abnormalities.
Eliminate blood clotting disorders before surgery or invasive procedures.
Suspicion of DIC syndrome (disseminated intravascular coagulation syndrome).
Suspicion of dysphibrinogenemia.
Suspicion of vitamin K deficiency.
When prone to bleeding (prolonged bleeding, frequent bleeding, bleeding from the nose and gums, spontaneous ecchymoses).
Venous thrombosis.

Fibrinogen

Suspicion of congenital or acquired fibrinogen deficiency.
Suspicion of excessive consumption of coagulation factors.
Monitoring of thrombolytic therapy.
Assess the risk of thrombotic complications, such as a heart attack or stroke in the presence of chronic heart disease.
Acute infections.
Frequent bleeding from the nose, gums, gastrointestinal tract, blood in the urine and / or stool.
Frequent bruises caused by minor trauma.
Bleeding for a long time and / or in case of abundant injury.
Blood clotting without adequate cause.
Evaluation of liver function.
You are taking blood thinner medications that are related to fibrinogen.
You have relatives with congenital disorders of blood clotting, fibrinogen.

It is advisable to perform the tests included in the complete coagulation profile:

For annual prophylactic examinations. The frequency of coagulation test for prophylaxis depends on the age of the patient: for young people it is recommended once a year, for the elderly - once every 6 months.
See also When infected with SARS-CoV-2, To prevent thrombosis.

The examination is prescribed by a doctor.

Possible interpretation of the results

aPTT

Prolongation of aPTT connected:

All congenital deficits (including hemophilia A and B, von Willebrand disease)
Thrombin inhibitors (hirudin, argatroban)
Streptokinase
Urokinase
Oral anticoagulant therapy
Vitamin K deficiency
Malnutrition
Intravascular coagulation syndrome
Existence of fibrin degradation products
Presence of circulating factor-specific anticoagulants
Nonspecific - Lupus anticoagulants

Normal PT (prothrombin time) prolonged aPTT: Deficiency of precalicine or one of the VIII, IX, XI and / or XII factors is likely.
Prolonged PT normal aPTT: A possible deficiency of factor VII is likely. Nutritional or therapeutic deficiency of vitamin K-dependent factors can sometimes lead to prolonged PT and normal aPTT.
Extended PT and aPTT: Deficiency of factor I, II, V or X is likely.

Reduction of aPTT connected:

Increased levels of one factor, most often factor VIII
Common neoplasms (except when the liver is damaged)
Acute bleeding
Early stage of DIC

A prolonged aPTT indicates hemorrhagic disease, and a decreased aPTT has been found to be an independent predictor of death in patients with a high risk of thrombosis and bleeding.

aPTT depends on the patient's age: in newborns, the upper limit of aPTT extends up to 55 seconds and gradually decreases to the values typical for adults by 6 months; Prolonged aPTT values in healthy children are caused by mild deficiencies of several coagulation proteins. In the elderly, aPTT may decrease.

PT

Prolongation of prothrombin means a delay in blood clotting and is manifested in the following cases:

Anticoagulant therapy.
Impaired liver function.
Insufficient amount of blood clotting proteins.
Vitamin K deficiency.
Deficiency of other coagulation factors (f. II, V, VII or X).
DIC syndrome.
Presence of blood clotting inhibitors.

Reduced prothrombin time means accelerated blood clotting and has no significant clinical significance. Manifested in the following cases:

Take vitamin K supplements.
Take large amounts of vitamin K products (green tea, liver, broccoli, soy).
Estrogen-containing drugs or hormone replacement therapy.

INR

The INR is evaluated in patients treated with oral anticoagulants and its determination serves to monitor dose and dose intervals.

Fibrinogen

Low levels of fibrinogen Can be found in the following cases:

Increased fibrinogen consumption in disseminated intravascular coagulation syndrome (DIC) and in case of excessive fibrin degradation in metastatic cancer, acute promyelocytic leukemia, obstetric complications.
Severe liver disease (decreased fibrinogen production).
Thrombolytic therapy.
L-asparaginase therapy.
Genetic diseases in the absence or deficiency of fibrinogen.
Moderate alcohol consumption.
The risk of bleeding during surgery is <50 mg / dL.

High levels of fibrinogen Can be found in the following cases:

Existence of systemic reaction of the organism to infections, inflammation, trauma, tumors, burns. In acute conditions, such as a heart attack or major surgery, fibrinogen levels return to normal after a critical period, on the other hand, in chronic inflammatory conditions (e.g., rheumatic and autoimmune diseases) fibrinogen levels remain high.
The body's compensatory response to protein loss from the kidneys during kidney disease and multiple myeloma.
Liver disease.
Estrogen treatment.
Hypertension, diabetes and overweight heart attack or stroke
With increased risk.

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