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The complement system is a component of the immune system that consists of more than 30 proteins and is involved in enhancing inflammatory responses, destroying pathogenic microorganisms, and removing damaged cells.
The complement system is also involved in autoimmune processes.
A complement component test is an analysis that measures the activity of a specific protein (complement component) in the blood.
A complement C2 component test is necessary when there is suspicion of hereditary or acquired deficiency of C2 component, which is associated with increased susceptibility to infections, autoimmune diseases, angioedema, lupus-associated vasculitis, glomerulonephritis, and others.
Complement C2 deficiency is the most common variant, occurring as a homozygous genetic disorder in 1 in 10,000–40,000 cases, and as a heterozygous form in 1%–2% of the general population. Patients with C2 deficiency and lupus often have negative or low titers of antinuclear antibodies (ANA) tests.”
Increase in indicators
Elevated complement levels most often indicate an inflammatory process, but can also be associated with infections, autoimmune diseases, metabolic disorders, and some neoplastic conditions:
In patients with an active autoimmune process (such as lupus), complement concentration and activity are often low.
Decrease in the indicator
A low level of the complement C2 component is characteristic of pathologies such as:
Determination of the complement C2 component has diagnostic value only in combination with other clinical and laboratory indicators. The study is not used for screening.
Preparation of the patient: no need
Study sample: Venous blood
Other tests
Testing process
| Purchase a test | Submission of material |
| Results Online | Consult a doctor |
