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Complement C2 component | Laboratory research

Also known as: C2 component of complement
SKU: 1452

80.00

Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: Yes
Country: EU

General Information

The complement system is a component of the immune system that consists of more than 30 proteins and is involved in enhancing inflammatory responses, destroying pathogenic microorganisms, and removing damaged cells.

The complement system is also involved in autoimmune processes.

A complement component test is an analysis that measures the activity of a specific protein (complement component) in the blood.

 

When should we take the test?

A complement C2 component test is necessary when there is suspicion of hereditary or acquired deficiency of C2 component, which is associated with increased susceptibility to infections, autoimmune diseases, angioedema, lupus-associated vasculitis, glomerulonephritis, and others.

 

Complement C2 deficiency is the most common variant, occurring as a homozygous genetic disorder in 1 in 10,000–40,000 cases, and as a heterozygous form in 1%–2% of the general population. Patients with C2 deficiency and lupus often have negative or low titers of antinuclear antibodies (ANA) tests.”

Possible interpretation of the results

Increase in indicators

Elevated complement levels most often indicate an inflammatory process, but can also be associated with infections, autoimmune diseases, metabolic disorders, and some neoplastic conditions:

  • Viral infections
  • Liver damage associated with dysmetabolism
  • Metabolic syndrome
  • Obesity
  • diabetes
  • Heart diseases
  • Psoriasis
  • წყლულოვანი კოლიტი

In patients with an active autoimmune process (such as lupus), complement concentration and activity are often low.

 

Decrease in the indicator

A low level of the complement C2 component is characteristic of pathologies such as:

  • Wolf
  • Liver cirrhosis and functional failure
  • Glomerulonephritis
  • Hereditary angioedema
  • Nutritional deficiency
  • Exacerbation of autoimmune diseases
  • Sepsis, or the presence of infection in the blood
  • Septic shock
  • Fungal infections
  • Parasitic infections

Reference values

Determination of the complement C2 component has diagnostic value only in combination with other clinical and laboratory indicators. The study is not used for screening.

 

Preparation of the patient: no need

Study sample: Venous blood

Testing process

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Submission of material

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This medical information is not intended to be a universal treatment guide for all patients. The treatment process, including the type, volume, and frequency of diagnostic tests and therapeutic procedures, is determined by the physician individually — based on an assessment of the patient's condition and relevant medical indications. The decision is made in consultation with the patient. Before purchasing a test, please read the instructions for its preparation.
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