Vitamin B12 | Laboratory research

Possible interpretation of the results

Increased concentration of vitamin B12:

• Liver diseases (acute hepatitis, cirrhosis, liver coma, liver metastases);
• Renal failure;
• Heart failure;
• Diabetes mellitus;
• Myeloproliferative diseases (acute and chronic myeloid leukemia, erythromyelosis, monocytic leukemia, lymphocytic leukemia);
• Treatment with vitamin B12.
• Protein deficiency.

Reduced concentration of vitamin B12:

Insufficient intake of vitamin:

• A strict vegetarian diet;
• Diet during phenylketonuria;
• Low content of vitamin in breast milk;

Malabsorption due to deficiency of internal factor in the gastric mucosa:

• Pernicious anemia;
• Total gastrectomy;
• Toxic damage to the gastric mucosa during chronic alcohol intoxication;

Impaired absorption of vitamin B12 and / or folic acid:

• Celiac disease;
• Resection of stomach, small intestine;
• Infection with Helicobacter pylori;
• Chronic inflammatory diseases (Crohn's disease, dysbiosis, chronic enteritis);
• Anatomical defects of the small intestine;
• Achlorhydria (atrophic gastritis, primary hypothyroidism, HIV infection);
• Parasitic infestations;
• Infiltrative diseases;
• Ileum radiation therapy (lymphomas, scleroderma);
• Alzheimer's disease;

Hereditary disorders of cobalamin metabolism:

• Transcobalamin deficiency;
• Hereditary selective malabsorption of vitamin B12;
• Hereditary pernicious anemia.