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Coagulation Is an ongoing process in the body that prevents excessive bleeding. However, the circulating blood in your blood vessels should not normally clot. In the event of a clot and blood clot (s), a blood clot can travel through your bloodstream to the heart, lungs, or brain, causing a heart attack, stroke, or even death.
Coagulation tests determine the ability of a blood to clot and the time it takes to clot. Testing will help your doctor assess the risk of developing excessive bleeding or thrombosis.
It is advisable to perform the tests included in the complete coagulation profile:
The examination is prescribed by a doctor.
Prolongation of aPTT connected:
Reduction of aPTT connected:
A prolonged aPTT indicates hemorrhagic disease, and a decreased aPTT has been found to be an independent predictor of death in patients with a high risk of thrombosis and bleeding.
aPTT depends on the patient's age: in newborns, the upper limit of aPTT extends up to 55 seconds and gradually decreases to the values typical for adults by 6 months; Prolonged aPTT values in healthy children are caused by mild deficiencies of several coagulation proteins. In the elderly, aPTT may decrease.
Prolongation of prothrombin means a delay in blood clotting and is manifested in the following cases:
Reduced prothrombin time means accelerated blood clotting and has no significant clinical significance. Manifested in the following cases:
The INR is evaluated in patients treated with oral anticoagulants and its determination serves to monitor dose and dose intervals.
The study of aPTT is a functional test that provides important information about the functioning of the coagulation system and certain factors.
This indicator is most commonly used to control and monitor therapy with non-fractional heparin and thrombin inhibitors (hirudin, argatroban). However, aPTT is not a first-line indicator when evaluating heparin treatment.
The test is also used to diagnose congenital or acquired insufficiency of certain coagulation factors (XII, XI, IX, VIII, VII) in case of suspected hemophilia or von Willebrand disease.
The aPTT test is used to detect the presence of specific or nonspecific coagulation inhibitors in the body - for example, lupus anticoagulant and antiphospholipid antibodies that are associated with clinical manifestations such as thrombosis.
It is also used as an indicator to assess the risk of bleeding before surgery.
Prothrombin is a protein synthesized by the liver and is one of the important factors that promotes blood clotting. Normal coagulation requires several types of proteins called coagulation factors. In the process of coagulation they must act properly and in sufficient quantities.
The assay determines the time (in seconds) during which a thrombus-producing protein called thrombin is produced from inactive prothrombin in the blood plasma taken for analysis.
It can detect both hypercoagulation and hypocoagulation.
PT is an important indicator of the condition of the coagulation system. It gives an idea of the activity of the factors involved in the external coagulation pathway (VII, X, V, I, II). Factors VII, X, V, I, II are synthesized in the liver and the process requires the presence of vitamin K.
Prothrombin time is measured in seconds, but can be expressed in different ways: seconds (sec), prothrombin index in percent (%) and INR (International Normalized Ratio).
Prothrombin activity in% is determined by analysis.
The analysis determines the relationship between prothrombin index (PI) and prothrombin time (PT).
It is comparable between different laboratories and according to its importance the doctor can determine the dose of prescribed anticoagulants and the interval between their reception.
INR is useful only in anticoagulant therapy and is not used to diagnose and treat patients with prolonged prothrombin time for other reasons.
Blood sampling is required for analysis Fasting, Without taking medication for the last 12 hours. The patient should be informed whether he or she is taking medications that affect blood clotting.
If you are taking blood thinners, Consult your doctor In connection with the examination.
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