Coagulation factor X

General Information

The tenth coagulation factor is a vitamin K-dependent glycoprotein, which participates in the process of blood clotting. It is converted to the active form by the participation of factor 7 and calcium with thromboplastin. Also factors 9, 8, calcium and platelet factor 3 activate it. Factor 10 is also involved in the formation of the prothrombinase complex by converting prothrombin to thrombin on the platelet phospholipid surface with the participation of calcium and activated factor 5.

Coagulation factor 10 deficiency can be either congenital or acquired. Acquired deficiency may be associated with anticoagulation therapy, liver disease, medications (eg, some antiarrhythmic medications), paraproteinemia, and amyloidosis.

Factor 10 deficiency is suspected when both prothrombin time (PT) and activated partial thromboplastin time (aPTT) are abnormal.

The congenital form of factor 10 deficiency is the result of an autosomal recessive gene mutation.

In case of factor 10 deficiency, bleeding in various organs may be detected.

Research material

Venous blood

advance preparation

The test is performed on an empty stomach. Before conducting the study, you should stop taking medications that affect the coagulation system.

When is the survey conducted?

The study is conducted to diagnose blood coagulation deficiency, bleeding diseases

norm indicator

m/w: 70 – 20%

Indicator norms may differ more or less in different laboratories.

Coagulation factor 10 deficiency is manifested in the following pathologies

Amyloidosis (abnormal protein synthesis in tissues and organs)

Congenital or acquired pathologies of coagulation (eg: massive blood loss)

Disseminated intravascular coagulation

Malabsorption (especially fat malabsorption)

Heparinization

Liver disease

Vitamin K deficiency

Long-term use of blood thinners