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Study material: Venous blood
Response time (working day): 14
The test is done on an empty stomach: no
Home call service: YesChromogranin A (CgA) is a blood test used to diagnose and monitor neuroendocrine tumors (NETs). It is a protein secreted by neuroendocrine cells, and its elevation is often associated with carcinoid tumors, pheochromocytoma, neuroblastoma, and other hormone-producing tumors.
Chromogranin A is a member of the granin family of proteins found in the secretory vesicles of neuroendocrine cells. Their function is to regulate the secretory activity of the cell.
Chromogranin is an important marker in tissue tumors such as carcinoid, pheochromocytoma, neuroblastoma, medullary thyroid carcinoma, pituitary tumors, pancreatic islet tumors, apudomas, and others.
Serum chromogranin A concentration correlates with tumor size. It is also a sensitive marker for predicting residual tumors and recurrence.
Some carcinoid tumors secrete chromogranin A along with serotonin and peptides.
Determination of chromogranin A is necessary in the diagnostics of neuroendocrine tumors.
Most carcinoid tumors are characterized by an increase in chromogranin A concentration. For maximum sensitivity of the study, it is best to simultaneously determine the concentration of chromogranin, serum serotonin, and urinary 5-HIIIA (5-hydroxy-indole acetoacetate). If all three parameters are negative, the presence of a carcinoid tumor is excluded.
Because chromogranin A is metabolized in the liver and excreted by the kidneys, patients with progressive hepatic and renal failure often have elevated chromogranin A levels, which reduces its laboratory value.
Drugs that stimulate neuroendocrine cells, especially proton pump inhibitors, significantly increase serum chromogranin A concentrations.
Proton pump inhibitors (“antacids”) should be discontinued for 1 week prior to collection of a sample for chromogranin A testing.
Research material – Venous blood
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