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C Reactive Protein (CRP)

Also known as: C reactive protein (CRP)
SKU: 1064


Study material: Venous blood
Response time (working day): 1
The test is done on an empty stomach: Yes
Home call service: Yes
Country: Georgia

General Information

C-reactive protein (CRP) Is a cyclic, acute phase protein that is synthesized by the liver during inflammation.

It is used as a reliable marker of the inflammatory process in the body. It grows rapidly but non-specifically in response to tissue damage and inflammation and is a more sensitive and rapid rate than EDS (erythrocyte sedimentation rate). If CRP levels are already elevated, EDS levels may still be normal.

When should we take the test?

  • Assessment of the degree of activity of inflammatory diseases;
  • Suspicion of bacterial infection based on the patient's medical history, objective signs and symptoms.
  • Suspicion of infection in newborns
  • Existence of symptoms of sepsis - fever, chills, rapid heartbeat and shortness of breath.
  • C-reactive protein can differentiate Crohn's disease (high CRP) from ulcerative colitis (low CRP) and rheumatoid arthritis (high CRP) from uncomplicated lupus erythematosus (low CRP);
  • Early detection of postoperative complications (if CRP levels remain high even after the third day of surgery, we may suspect the presence of infection);
  • Detection of transplant rejection;
  • Detection of intrauterine infections associated with premature rupture of membranes;
  • Evaluation of myocardial infarction or reinfarction after myocardial infarction;
  • Monitoring of antibiotic therapy during bacterial infections;
  • Monitoring of anti-inflammatory therapy in rheumatic diseases.

CRP is a valuable marker for diagnosing and monitoring the effects of acute inflammatory diseases, especially in intensive care units and young children.

Possible interpretation of the results

CRP concentration increases:

  • Inflammation, tissue necrosis, trauma;
  • Myocardial infarction;
  • Diseases of the gastrointestinal tract;
  • Graft rejection reaction;
  • Malignant tumors;
  • Secondary amyloidosis;
  • Systemic rheumatoid diseases;
  • Neonatal sepsis;
  • Meningitis;
  • Tuberculosis;
  • Postoperative complications;
  • Neutropenia.

Additional information

The physiological role of CRP is complex:

  • By a calcium-dependent mechanism it binds to phosphoryl-choline residues of many phospholipids, especially pneumococcal C polysaccharides (hence its name);
  • Binds to chromatin and histone and participates in the clearance of cell debris;
  • Binds to phagocytes and accelerates the phagocytosis of antigens and microorganisms;
  • Participates in the activation of the complement in the classical way;
  • Binds to LDL lipoproteins and is likely to play an important role in their removal from atherosclerotic plaque.
  • CRP itself is "inflammatory" because it stimulates the production of IL-1, IL-6 and TNF-α by monocytes. Although the major source of CRP is the liver, recent data indicate that arterial tissue can produce both CRP and proteins that belong to the complement system. CRP levels can increase dramatically (100 times or more) after severe trauma, bacterial infections, inflammation, surgery.

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