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C-peptide Is a stable fragment of endogenously produced proinsulin that is "cleaved" from it during insulin production. It consists of 31 amino acid residues, is located between the alpha and beta chains of proinsulin and is biologically inactive. Once the insulin molecule is synthesized in the pancreatic beta cells, the C-peptide is released into the bloodstream along with insulin. Insulin is inactive before the C-peptide is removed, which allows the pancreas to store insulin as a prohormone. It should be noted that although the number of C-peptide and insulin molecules produced during secretion is the same, the equilibrium concentration of C-peptide in the blood is approximately 5 times the molar concentration of insulin, which is related to the different rate of their elimination from the blood.
C-peptide concentration decreases:
Determining the level of C-peptide allows us to assess the level of insulin secretion. C-peptide determination has a number of advantages over insulin determination: The half-life of C-peptide in the blood is longer than that of insulin, so C-peptide levels are more stable than insulin concentrations. Determination of C-peptide makes it possible to assess insulin secretion even when taking exogenous insulin, as well as in the presence of autoantibodies to insulin, which is important in the examination of patients with type 1 diabetes.
C-peptide levels change according to changes in endogenous insulin concentration. The ratio of these parameters may change in the setting of liver and kidney disease because insulin is metabolized primarily in the liver while C-peptide metabolism and excretion are mediated by the kidneys. Accordingly, the determination of this indicator may be the main, in case of impaired liver function, adequate interpretation of changes in insulin concentration in the blood.
Monitoring of C-peptide levels is especially important in patients after surgical treatment of insulinoma; Elevated levels of C-peptide in the blood indicate metastases or tumor recurrence.
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More than 1000 routine and complex/specific diagnostic tests in all major areas of clinical pathology.
48 laboratory centers in 25 cities of Georgia: Tbilisi, Rustavi, Kutaisi, Batumi, Marneuli, Telavi, Zugdidi, Zestafon, Gori, Kobuleti, Akhaltsikhe, Khashuri, Sartichala, Kazbegi, Borjomi, Samtredia, Gurjaani, Lagodekhi, Akhmeta, Ozurgeti, Poti, Chiatura , Dusheti, Kareli, New Gudauri.
Use the Synevo web platform to view results from anywhere and anytime
Use the Synevo web platform to view results from anywhere, anytime
From Monday to Saturday you can use the laboratory services at home.
☎️ Hotline: 239 38 33 or 239 40 65
577293008 (9:00-დან 17:00-მდე)
30 laboratory centers in 11 cities of Georgia: Tbilisi, Kutaisi, Batumi, Kobuleti, Zugdidi, Zestaponi, Rustavi, Marneuli, Akhaltsikhe, Telavi, Gori.
More than 3000 routine and complex / specific diagnostic tests in all major areas of clinical pathology.
"Synevo" - Providing a wide range of diagnostic services in Georgia, offering more than 1,000 routine and specific diagnostic tests in all major areas of clinical pathology. By the end of 2023, the Synevo Georgia network will include 3 clinical laboratories and 47 blood sampling units, which will perform more than 300,000 tests.
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Address: Tsinandali St. N9 (N1 Clinical Hospital area)
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